Ppif - peptidylprolyl isomerase F (cyclophilin F) Gene

Mus musculus

Also known as CypD; CyP-D; CyP-F; PPIase

Gene ID: 105675 | Gene type: protein coding

About Ppif

Summary

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including negative regulation of ATPase activity; positive regulation of release of cytochrome c from mitochondria; and regulation of proton transport. Acts upstream of or within apoptotic mitochondrial changes; necroptotic process; and response to oxidative stress. Located in mitochondrion. Part of mitochondrial permeability transition pore complex. Is expressed in lower jaw tooth and tooth. Orthologous to human PPIF (peptidylprolyl isomerase F). [provided by Alliance of Genome Resources, Apr 2022]

Ppif Products(1)

mRNA	Protein	Name
NM_134084.1	NP_598845.1	peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22726440	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic mitochondrial changes	IGI IGI: Inferred from genetic interaction	18350175	MGI
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	19293339	MGI
involved in cellular response to arsenic-containing substance	IMP IMP: Inferred from mutant phenotype	21281446	MGI
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	15800626	MGI
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	15800626	MGI
acts upstream of or within mitochondrial depolarization	IGI IGI: Inferred from genetic interaction	19293339	MGI
acts upstream of or within mitochondrion organization	IGI IGI: Inferred from genetic interaction	19293339	MGI
acts upstream of or within muscle structure development	IGI IGI: Inferred from genetic interaction	19293339	MGI
acts upstream of or within necroptotic process	IGI IGI: Inferred from genetic interaction	22726440	MGI
involved in negative regulation of ATP-dependent activity	IMP IMP: Inferred from mutant phenotype	21281446	MGI
involved in negative regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	21281446	MGI
involved in negative regulation of oxidative phosphorylation uncoupler activity	IMP IMP: Inferred from mutant phenotype	21281446	MGI
involved in programmed cell death	IMP IMP: Inferred from mutant phenotype	15800627	MGI
acts upstream of or within regulation of mitochondrial membrane permeability	IGI IGI: Inferred from genetic interaction	22726440	MGI
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	16103352	MGI
involved in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	15800626	MGI
involved in regulation of proton-transporting ATPase activity, rotational mechanism	IMP IMP: Inferred from mutant phenotype	19801635	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	15800626	MGI
acts upstream of or within response to oxidative stress	IGI IGI: Inferred from genetic interaction	22726440	MGI
acts upstream of or within skeletal muscle fiber differentiation	IGI IGI: Inferred from genetic interaction	19293339	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial permeability transition pore complex	IMP IMP: Inferred from mutant phenotype	31489369	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase F, mitochondrial

PPIase F	cyclophilin D
cyclophilin F	mitochondrial Cyclophilin D
peptidyl-prolyl cis-trans isomerase, mitochondrial	rotamase F

Ppif Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ppif	Q99KR7	Tp53	Mus musculus	P02340	Anti Bait CoIP	22726440

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10951	PPIF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppif	NCBI	NCBI:10105

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