PPIF - peptidylprolyl isomerase F Gene

Homo sapiens

Also known as CYP3; CypD; CyP-M; Cyp-D

Gene ID: 10105 | Gene type: protein coding

About PPIF

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:79,347,469-79,355,334 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 22 paralogues. Ubiquitous expression in adrenal (RPKM 72.6), bone marrow (RPKM 44.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]

PPIF Products(1)

mRNA	Protein	Name
NM_005729.4	NP_005720.1	peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	20676357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22726440	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	22726440	GOA
involved in mitochondrial outer membrane permeabilization involved in programmed cell death	IMP IMP: Inferred from mutant phenotype	26387735	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19228691	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19228691	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	19228691	GOA
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	26387735	GOA
involved in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	22726440	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial permeability transition pore complex	IDA IDA: Inferred from direct assay	26387735	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIF Protein Structure

Pro_isomerase

0
100
207 a.a.

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase F, mitochondrial

PPIase F

PPIF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	PPIF	P30405	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	PPIF	P30405	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	PRB3	Homo sapiens	Q04118	Y2H Array	32296183
Intra	PPIF	P30405	PRB3	Homo sapiens	Q04118	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	PRB3	Homo sapiens	Q04118	Validated Y2H	32296183
Intra	PPIF	P30405	FAM25C	Homo sapiens	B3EWG5	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	FAM25C	Homo sapiens	B3EWG5	Y2H Array	32296183
Intra	PPIF	P30405	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	PPIF	P30405	CMTM5	Homo sapiens	Q96DZ9	Y2H Prey Pooling	25416956
Intra	PPIF	P30405	CMTM5	Homo sapiens	Q96DZ9	Validated Y2H	25416956
Intra	PPIF	P30405	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	PPIF	P30405	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	PPIF	P30405	SYPL1	Homo sapiens	Q16563	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	SYPL1	Homo sapiens	Q16563	Validated Y2H	32296183
Intra	PPIF	P30405	SYPL1	Homo sapiens	Q16563	Y2H Array	32296183
Intra	PPIF	P30405	TP53	Homo sapiens	P04637	Anti Bait CoIP	22726440
Intra	PPIF	P30405	TP53	Homo sapiens	P04637	Pull Down	22726440
Intra	PPIF	P30405	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	PPIF	P30405	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	PPIF	P30405	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	ARFIP2	Homo sapiens	P53365	Validated Y2H	32296183
Intra	PPIF	P30405	ARFIP2	Homo sapiens	P53365	Y2H Array	32296183
Intra	PPIF	P30405	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	PPIF	P30405	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	PPIF	P30405	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	PPIF	P30405	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	MAGEA11	Homo sapiens	P43364	Validated Y2H	32296183
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9	Y2H Array	25416956
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	PPIF	P30405	BANP	Homo sapiens	Q8N9N5	Y2H Prey Pooling	25416956
Intra	PPIF	P30405	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	PPIF	P30405	BANP	Homo sapiens	Q8N9N5	Y2H Array	25416956
Intra	PPIF	P30405	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	SPR	32825572
Intra	PPIF	P30405	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	PPIF	P30405	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74211	Cyclophilin F/PPIF Protein, Human (HEK293, His, solution)	P30405 (C30-S207)	≥95%

PPIF Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82857	Cyclophilin F Antibody (YA2602)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy	Ullrich Disease
Ucmd	Ullrich Scleroatonic Muscular Dystrophy
Scleroatonic Muscular Dystrophy	UCMD1
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22	Lgmdr22
Muscular Dystrophy, Scleroatonic	Late Onset Scleroatonic Familial Myopathy
Congenital Muscular Dystrophy, Ullrich Type

Bethlem Myopathy 1

Bethlem Myopathy	Myopathy, Benign Congenital, With Contractures
Muscular Dystrophy, Benign Congenital	BTHLM1
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 5	Lgmdd5
Benign Congenital Muscular Dystrophy	Benign Autosomal Dominant Myopathy
Myopathy, Bethlem	Myopathy, Bethlem, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10951	PPIF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPIF	VGNC	VGNC:33198
Mus musculus	PPIF	MGD	MGI:2145814
Felis catus	PPIF	VGNC	VGNC:97563
Rattus norvegicus	PPIF	RGD	RGD:628670
Macaca mulatta	PPIF	VGNC	VGNC:81510
Others	PPIF	NCBI

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