Trp53 - transformation related protein 53 Gene

Mus musculus

Also known as bbl; bfy; bhy; p44; p53; Tp53

Gene ID: 22059 | Gene type: protein coding

About Trp53

Chromosome 11: 69,471,185-69,482,699 forward strand.GRCm39:CM001004.3

This gene has 6 transcripts (splice variants), 251 orthologues, 2 paralogues and is associated with 250 phenotypes. Ubiquitous expression in thymus adult (RPKM 69.1), ovary adult (RPKM 56.5) and 28 other tissues.

Summary

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, Apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Trp53 Products(2)

mRNA	Protein	Name
NM_001127233.1	NP_001120705.1	cellular tumor antigen p53 isoform b
NM_011640.3	NP_035770.2	cellular tumor antigen p53 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21159655	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	16286009	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12135983	MGI
enables MDM2/MDM4 family protein binding	IPI IPI: Inferred from physical interaction	20818388	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10205143	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22897442	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15657445	MGI
enables histone deacetylase regulator activity	IDA IDA: Inferred from direct assay	15657445	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9194565	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24240685	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell lineage commitment	IMP IMP: Inferred from mutant phenotype	8788039	MGI
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	14744935	MGI
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	11092819	MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	11790307	MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator	IGI IGI: Inferred from genetic interaction	16199867	MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IGI IGI: Inferred from genetic interaction	16107883	MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA IDA: Inferred from direct assay	10710310	MGI
acts upstream of or within T cell differentiation in thymus	IGI IGI: Inferred from genetic interaction	16357222	MGI
acts upstream of or within T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	8788039	MGI
acts upstream of or within T cell proliferation involved in immune response	IGI IGI: Inferred from genetic interaction	16357222	MGI
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	16183742	MGI
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	17325035	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	17912366	MGI
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17434459	MGI
acts upstream of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within cardiac septum morphogenesis	IGI IGI: Inferred from genetic interaction	22821713	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	10973261	MGI
involved in cellular response to UV	IDA IDA: Inferred from direct assay	23629966	MGI
acts upstream of or within cellular response to UV	IGI IGI: Inferred from genetic interaction	14963330	MGI
acts upstream of or within cellular response to UV-C	IGI IGI: Inferred from genetic interaction	24014029	MGI
acts upstream of or within cellular response to gamma radiation	IDA IDA: Inferred from direct assay	10710310	MGI
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	16213212	MGI
acts upstream of or within cellular response to ionizing radiation	IGI IGI: Inferred from genetic interaction	16286009	MGI
acts upstream of or within cellular response to stress	IGI IGI: Inferred from genetic interaction	26158450	MGI
acts upstream of or within central nervous system development	IGI IGI: Inferred from genetic interaction	16199867	MGI
acts upstream of or within cerebellum development	IDA IDA: Inferred from direct assay	24013501	MGI
acts upstream of or within chromosome organization	IGI IGI: Inferred from genetic interaction	17053789	MGI
involved in circadian behavior	IMP IMP: Inferred from mutant phenotype	24051492	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	24051492	MGI
involved in determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	20818388	MGI
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	17912366	MGI
acts upstream of or within embryo development ending in birth or egg hatching	IGI IGI: Inferred from genetic interaction	16702401	MGI
acts upstream of or within embryonic organ development	IGI IGI: Inferred from genetic interaction	17470788	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	24051492	MGI
acts upstream of fibroblast proliferation	IGI IGI: Inferred from genetic interaction	16107883	MGI
acts upstream of or within fibroblast proliferation	IGI IGI: Inferred from genetic interaction	26334721	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	17332504	MGI
acts upstream of or within gastrulation	IGI IGI: Inferred from genetic interaction	17000767	MGI
acts upstream of glial cell proliferation	IGI IGI: Inferred from genetic interaction	10973261	MGI
acts upstream of glucose catabolic process to lactate via pyruvate	IMP IMP: Inferred from mutant phenotype	20935145	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	22821713	MGI
NOT acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	9425892	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	9288110	MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	12135983	MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator	IGI IGI: Inferred from genetic interaction	20434500	MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: Inferred from direct assay	16213212	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI IGI: Inferred from genetic interaction	15983387	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	12135983	MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	20818388	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	16407291	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to hypoxia	IMP IMP: Inferred from mutant phenotype	20935145	MGI
acts upstream of or within mitochondrial DNA repair	IMP IMP: Inferred from mutant phenotype	24101517	MGI
acts upstream of mitophagy	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within mitotic G1 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	16107883	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	17116431	MGI
acts upstream of or within necroptotic process	IGI IGI: Inferred from genetic interaction	22726440	MGI
acts upstream of or within negative regulation of DNA replication	IDA IDA: Inferred from direct assay	11884608	MGI
acts upstream of or within negative regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	11884608	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	24051492	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19749791	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	8183579	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10591652	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19749791	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IGI IGI: Inferred from genetic interaction	16107883	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	12952892	MGI
acts upstream of or within negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	18625840	MGI
acts upstream of or within negative regulation of glial cell proliferation	IGI IGI: Inferred from genetic interaction	10973261	MGI
acts upstream of or within negative regulation of glucose catabolic process to lactate via pyruvate	IMP IMP: Inferred from mutant phenotype	20935145	MGI
acts upstream of or within negative regulation of miRNA processing	IGI IGI: Inferred from genetic interaction	21522133	MGI
acts upstream of or within negative regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within negative regulation of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	8612582	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	9608530	MGI
acts upstream of or within negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	23277542	MGI
acts upstream of or within negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	10591653	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8183579	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15657445	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19749791	MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15657445	MGI
acts upstream of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	9608530	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10911993	MGI
acts upstream of or within neuron apoptotic process	IGI IGI: Inferred from genetic interaction	15485914	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9608530	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17591690	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15735665	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	15735665	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	9024662	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17068116	MGI
acts upstream of or within positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within positive regulation of cellular senescence	IGI IGI: Inferred from genetic interaction	17053789	MGI
involved in positive regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	10562313	MGI
acts upstream of or within positive regulation of mitochondrial membrane permeability	IGI IGI: Inferred from genetic interaction	22726440	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	10894779	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10911993	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9608530	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	19749791	MGI
involved in positive regulation of programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	27258785	MGI
acts upstream of or within positive regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	17210642	MGI
involved in positive regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	20818388	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7677753	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22362889	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20434500	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16407291	MGI
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	11799106	MGI
acts upstream of or within protein stabilization	IGI IGI: Inferred from genetic interaction	18625840	MGI
acts upstream of or within rRNA transcription	IGI IGI: Inferred from genetic interaction	18809582	MGI
acts upstream of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within regulation of DNA damage response, signal transduction by p53 class mediator	IGI IGI: Inferred from genetic interaction	21522133	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12135983	MGI
acts upstream of or within regulation of cell cycle	IGI IGI: Inferred from genetic interaction	18332125	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	15898111	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10716720	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12878730	MGI
acts upstream of or within regulation of cellular senescence	IGI IGI: Inferred from genetic interaction	22904064	MGI
acts upstream of or within regulation of fibroblast apoptotic process	IGI IGI: Inferred from genetic interaction	17116431	MGI
acts upstream of or within regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17571083	MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in apoptotic process	IGI IGI: Inferred from genetic interaction	14963330	MGI
acts upstream of or within regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	17515607	MGI
acts upstream of or within regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	15483136	MGI
acts upstream of or within regulation of thymocyte apoptotic process	IGI IGI: Inferred from genetic interaction	17210642	MGI
acts upstream of or within regulation of tissue remodeling	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24013501	MGI
acts upstream of or within release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	15483136	MGI
acts upstream of or within release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	14963330	MGI
acts upstream of or within response to UV	IDA IDA: Inferred from direct assay	14744935	MGI
acts upstream of or within response to UV	IMP IMP: Inferred from mutant phenotype	10815637	MGI
acts upstream of or within response to X-ray	IDA IDA: Inferred from direct assay	11884608	MGI
acts upstream of or within response to X-ray	IMP IMP: Inferred from mutant phenotype	22821713	MGI
acts upstream of or within response to gamma radiation	IDA IDA: Inferred from direct assay	14744935	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	17068116	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within response to oxidative stress	IGI IGI: Inferred from genetic interaction	22726440	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	17591690	MGI
acts upstream of or within response to salt stress	IGI IGI: Inferred from genetic interaction	16571598	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	9098922	MGI
acts upstream of or within signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	26334721	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	17320900	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	10591653	MGI
acts upstream of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	17210642	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18212064	MGI
involved in type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23629966	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11799106	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11799106	MGI
located in germ cell nucleus	IDA IDA: Inferred from direct assay	12524542	MGI
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	22726440	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	12667443	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11799106	MGI
located in replication fork	IDA IDA: Inferred from direct assay	15364958	MGI
located in site of double-strand break	IDA IDA: Inferred from direct assay	24550317	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Trp53 Protein Structure

P53_TAD

P53

P53_tetramer

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

cellular tumor antigen p53

ME-delta123p53	mutant p53
p53 cellular tumor antigen	tumor suppressor p53
tumor supressor p53

Trp53 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tp53	P02340	Pten	Mus musculus	O08586	Anti Bait CoIP	23123091
Intra	Tp53	P02340	Sod2	Mus musculus	P09671	Anti Bait CoIP	21909133
Intra	Tp53	P02340	Pin1	Mus musculus	Q9QUR7	Anti Bait CoIP	21741598
Intra	Tp53	P02340	Bach1	Mus musculus	P97302	Anti Bait CoIP	19011633
Cross	Tp53	P02340	BCL2L1	Homo sapiens	Q07817-1	Anti Bait CoIP	16151013
Intra	Tp53	P02340	Trim24	Mus musculus	Q64127	TAP	19556538
Intra	Tp53	P02340	Mdm2	Mus musculus	P23804-1	Anti Bait CoIP	20697359
Intra	Tp53	P02340	Smarcd1	Mus musculus	Q61466	Y2H	18303029
Intra	Tp53	P02340	Smarcd1	Mus musculus	Q61466	Anti Tag CoIP	18303029
Intra	Tp53	P02340	Ep300	Mus musculus	B2RWS6	Crosslink	25117711
Intra	Tp53	P02340	Ep300	Mus musculus	B2RWS6	Anti Bait CoIP	9194565
Intra	Tp53	P02340	Rps27a	Mus musculus	P62991	Anti Bait CoIP	21857681
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	18448518
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	21122074
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	28536627
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	26960425
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	20621096
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	10329544
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	23980194
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	16480949
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	21670284
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	18025262
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Y2H	37025149
Cross	Tp53	P02340	lt_sv40	Simian virus 40	P03070	Anti Bait CoIP	10637512
Intra	Tp53	P02340	Mdm2	Mus musculus	P23804	Anti Bait CoIP	21857681
Intra	Tp53	P02340	Mdm2	Mus musculus	P23804	TAP	19556538
Intra	Tp53	P02340	Mdm2	Mus musculus	P23804	Anti Bait CoIP	17936560
Intra	Tp53	P02340	Polg	Mus musculus	P54099	Anti Bait CoIP	21909133

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15102	Trp53 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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