SIVA1 - SIVA1 apoptosis inducing factor Gene

Homo sapiens

Also known as SIVA; CD27BP; Siva-1; Siva-2

Gene ID: 10572 | Gene type: protein coding

About SIVA1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:104,753,147-104,759,654 (from NCBI)

This gene has 8 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in bone marrow (RPKM 15.7), fat (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin Ligase that regulates cell cycle progression, cell proliferation and Apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]

SIVA1 Products(2)

mRNA	Protein	Name
NM_006427.4	NP_006418.2	apoptosis regulatory protein Siva isoform 1
NM_021709.3	NP_068355.1	apoptosis regulatory protein Siva isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CD27 receptor binding	IPI IPI: Inferred from physical interaction	9177220	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9177220	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	16683188	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation-induced cell death of T cells	IDA IDA: Inferred from direct assay	16491128	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9177220	GOA
NOT involved in intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	12011449	GOA
involved in intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	12011449	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16491128	GOA
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15034012	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12011449	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	12011449	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	15034012	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIVA1 Protein Structure

Siva

0
100
175 a.a.

Protein Preferred Names

Protein Names

apoptosis regulatory protein Siva

CD27-binding (Siva) protein

SIVA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIVA1	O15304	PXMP2	Homo sapiens	Q9NR77	Pull Down	16683188
Intra	SIVA1	O15304	BCL2L1	Homo sapiens	Q07817-1	Anti Bait CoIP	12011449
Intra	SIVA1	O15304	CD27	Homo sapiens	P26842	Anti Bait CoIP	9177220
Intra	SIVA1	O15304	BCL2L1	Homo sapiens	Q07817	Pull Down	14739602
Cross	SIVA1	O15304	E7	Human papillomavirus	P03129	Peptide Array	17348035
Cross	SIVA1	O15304	E7	Human papillomavirus	P03129	Y2H	17348035

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12957	SIVA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SIVA1	RGD	RGD:1561872
Mus musculus	SIVA1	MGD	MGI:1353606
Felis catus	SIVA1	VGNC	VGNC:65162
Bos taurus	SIVA1	VGNC	VGNC:34638

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