PXMP2 - peroxisomal membrane protein 2 Gene

Homo sapiens

Also known as PMP22; MPV17L3

Gene ID: 5827 | Gene type: protein coding

About PXMP2

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,687,587-132,704,985 (from NCBI)

This gene has 5 transcripts (splice variants), 172 orthologues and 3 paralogues. Broad expression in liver (RPKM 47.9), kidney (RPKM 25.6) and 25 other tissues.

Summary

Located in peroxisomal membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

PXMP2 Products(1)

mRNA	Protein	Name
NM_018663.3	NP_061133.1	peroxisomal membrane protein 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11590176	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8624723	GOA
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	11590176	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	18174172	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PXMP2 Protein Structure

Mpv17_PMP22

0
100
195 a.a.

Protein Preferred Names

Protein Names

peroxisomal membrane protein 2

22 kDa peroxisomal membrane protein

PXMP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PXMP2	Q9NR77	SIVA1	Homo sapiens	O15304	Y2H	16683188
Intra	PXMP2	Q9NR77	SIVA1	Homo sapiens	O15304	Pull Down	16683188
Intra	PXMP2	Q9NR77	PEX19	Homo sapiens	P40855	Anti Tag CoIP	14709540

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11482	PXMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PXMP2	RGD	RGD:61812
Mus musculus	PXMP2	MGD	MGI:107487
Macaca mulatta	PXMP2	VGNC	VGNC:76628
Bos taurus	PXMP2	VGNC	VGNC:33584
Felis catus	PXMP2	VGNC	VGNC:80470
Canis familiaris	PXMP2	VGNC	VGNC:45220

Name
Email *

	Sorry, but the email address you supplied was invalid.