Scrib - scribbled planar cell polarity Gene

Mus musculus

Also known as Crc; CRIB; Scrb1; SCRIB1; vartul; mKIAA0147

Gene ID: 105782 | Gene type: protein coding

About Scrib

Summary

Involved in several processes, including establishment of T cell polarity; negative regulation of activated T cell proliferation; and synaptic vesicle cycle. Acts upstream of or within several processes, including nervous system development; post-anal tail morphogenesis; and wound healing. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; hair follicle; and nervous system. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]

Scrib Products(3)

mRNA	Protein	Name
NM_001310542.1	NP_001297471.1	protein scribble homolog isoform 2
NM_001310543.1	NP_001297472.1	protein scribble homolog isoform 3
NM_134089.2	NP_598850.1	protein scribble homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16611247	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within auditory receptor cell morphogenesis	IGI IGI: Inferred from genetic interaction	20215345	MGI
acts upstream of or within auditory receptor cell stereocilium organization	IGI IGI: Inferred from genetic interaction	20215345	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18716323	MGI
acts upstream of or within cochlear nucleus development	IGI IGI: Inferred from genetic interaction	20215345	MGI
involved in establishment of T cell polarity	IDA IDA: Inferred from direct assay	18329370	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	21515572	MGI
involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	19041750	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	12499390	MGI
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	18329370	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	21515572	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	20643356	MGI
involved in positive chemotaxis	IMP IMP: Inferred from mutant phenotype	18716323	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	18329370	MGI
acts upstream of or within post-anal tail morphogenesis	IGI IGI: Inferred from genetic interaction	21515572	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	21515572	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	16687519	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	19458197	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	19458197	MGI
involved in synaptic vesicle targeting	IMP IMP: Inferred from mutant phenotype	19458197	MGI
acts upstream of or within wound healing	IGI IGI: Inferred from genetic interaction	20643356	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16687519	MGI
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	22333836	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	18329370	MGI
located in myelin sheath abaxonal region	IDA IDA: Inferred from direct assay	20237282	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein scribble homolog

PDZ-domain protein scribble	circletail
scribble homolog 1	scribbled homolog

Scrib Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Scrib	Q80U72	Crtam	Mus musculus	Q149L7	Confocal	18329370
Cross	Scrib	Q80U72	PHLPP1	Homo sapiens	O60346	Anti Tag CoIP	21701506

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12562	SCRIB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scrib	NCBI	NCBI:23513

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