1. Gene
  2. CES1 - carboxylesterase 1 Gene

CES1 - carboxylesterase 1 Gene

Homo sapiens

Also known as CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1

Gene ID: 1066 | Gene type: protein coding

About CES1

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,802,851-55,833,096 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 667 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 737.7), gall bladder (RPKM 239.9) and 3 other tissues.

Summary

This gene encodes a member of the Carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and Cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This Enzyme is the major liver Enzyme and functions in liver drug clearance. Mutations of this gene cause Carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

CES1 Products(3)

mRNA Protein Name
NM_001025194.2 NP_001020365.1 liver carboxylesterase 1 isoform b precursor
NM_001025195.2 NP_001020366.1 liver carboxylesterase 1 isoform a precursor
NM_001266.5 NP_001257.4 liver carboxylesterase 1 isoform c precursor

CES1 Protein Structure

COesterase

COesterase: Carboxylesterase family (2 - 547)

  • 0
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  • 500
  • 567 a.a.
Protein Preferred Names Protein Names

liver carboxylesterase 1

acyl coenzyme A:cholesterol acyltransferase

Recombinant CES1 Proteins

Cat. No. Product Name Accession Purity
HY-P7730 Carboxylesterase 1 Protein, Human (HEK293, His) P23141-3 (H19-E562) ≥95%

Related Diseases

Diseases Alias
Drug Metabolism, Altered, Ces1-Related
Egasyn

Esterase 22

Es22

Alveolar Echinococcosis

Echinococcus Multilocularis Infection

Echinococcosis

Alveolococcosis

Multilocular Hydatid

Small Fox Tapeworm

Cystic Echinococcosis

Echinococcus Granulosus Infection

Echinococcus Granulosus Infection Of Lung

Echinococcus Granulosus

Echinococcus Granulosus Infection Of Thyroid

Echinococcus Granulosus Infectious Disease

Echinococcus Granulosus Infectious Disease Of Liver

Echinococcus Granulosus Infectious Disease Of Thyroid

Liver Echinococcus Granulosus

Lung Echinococcus Granulosus

Thyroid Echinococcus Granulosus

Unilocular Echinococcosis

Unilocular Hydatid Disease

Hydatid Disease

Hydatidosis

Echinococcosis

Reye Syndrome

Reye'S Syndrome

Rasmussen Encephalitis

Fatty Liver With Encephalopathy

Rasmussen'S Encephalitis

Re

Rs

Rasmussen Syndrome

Liver Fatty Metamorphosis--Acute Encephalopathy Syndrome

Reye Encephalopathy

Large Intestine Adenoma

Adenoma Of Large Intestine

Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis

Echinococcosis

Hydatidosis

Echinococcal Disease

Echinococcosis Of Liver

Hepatic Echinococcosis

Hydatid Disease

Liver Echinococcus

Pulmonary Echinococcosis

Hydatids

Echinococcosis, Hepatic

Echinococcosis, Pulmonary

Unilocular Echinococcosis

Echinococcus Disease

Echinococcus Granulosus Infection

Echinococcus Multilocularis Infection

Dog Tapeworm Infection

Echinococcus Granulosus Infestation

Echinococciasis

Cystic Echinococcosis

Taeniasis

Beef Tapeworm Infection

Infection By Taeniarhynchus Saginatus

Taenia Saginata Infectious Disease

Taenia Saginata Infection

Pork Tapeworm Infection

Armed Tapeworm Infection

Infection By Taenia Solium

Intestinal Taenia Solium Infection

Pork Tapeworm

Taenia Solium Taeniasis

Adult Pork Tapeworm Infection

Adult Pork Tapeworm

Beef Tapeworm

Infection By Taenia Saginata

Unarmed Tapeworm Infection

Taenia Saginata Taeniasis

Infection Due To Adult Tapeworm Taenia Saginata

Mediocanellata Taenia Infection

Infestation By Taenia Saginata

Infestation By Taenia Mediocanellata

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis

Niemann-Pick Diseases

Lipoid Histiocytosis

Sphingomyelin Lipidosis

Sphingomyelinase Deficiency Disease

Lipid Histiocytosis

Neuronal Cholesterol Lipidosis

Neuronal Lipidosis

Npd

Sphingomyelinase Deficiency

Niemann-Pick Disease, Type A

Retinitis Pigmentosa 44

RP44

Retinitis Pigmentosa, Type 44

Glossopharyngeal Neuralgia

Glossopharyngeal Nerve Diseases

Parasitic Helminthiasis Infectious Disease

Helminthiasis

Intestinal Helminthiasis

Helminth Infection

Helminthosis

Worm Infection

Worm Infections

Helminth Infections

Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

Parasitic Enteritis

Metazoal Dysentery

Intestinal Worms Nos

Cysticercosis

Neurocysticercosis

Submacular Cysticercosis

Intestinal Taenia Solium Infection

Pork Tapeworm Infection

Tapeworm Infection: Intestinal Taenia Solum

Tapeworm Infection: Pork

Tenia Solium Infectious Disease

Taeniasis

Tenia Solium Infection

Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris CES1 VGNC VGNC:52121
Rattus norvegicus CES1 RGD RGD:70896
Mus musculus CES1 NCBI