POLD3 - DNA polymerase delta 3, accessory subunit Gene

Homo sapiens

Also known as P66; P68; PPP1R128

Gene ID: 10714 | Gene type: protein coding

About POLD3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,592,582-74,669,341 (from NCBI)

This gene has 10 transcripts (splice variants) and 37 orthologues. Ubiquitous expression in testis (RPKM 7.5), colon (RPKM 6.2) and 25 other tissues.

Summary

This gene encodes the 66-kDa subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA Polymerase delta through interactions with Other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

POLD3 Products(2)

mRNA	Protein	Name
NM_001363597.2	NP_001350526.1	DNA polymerase delta subunit 3 isoform 2
NM_006591.3	NP_006582.1	DNA polymerase delta subunit 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15576034	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	11595739	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA biosynthetic process	IDA IDA: Inferred from direct assay	11595739	GOA
involved in DNA-templated DNA replication	IDA IDA: Inferred from direct assay	20334433	GOA
involved in error-prone translesion synthesis	IDA IDA: Inferred from direct assay	24449906	GOA
involved in nucleotide-excision repair, DNA gap filling	IMP IMP: Inferred from mutant phenotype	20227374	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of delta DNA polymerase complex	IDA IDA: Inferred from direct assay	11595739	GOA
part of delta DNA polymerase complex	IPI IPI: Inferred from physical interaction	12403614	GOA
part of zeta DNA polymerase complex	IDA IDA: Inferred from direct assay	22465957	GOA
part of zeta DNA polymerase complex	IPI IPI: Inferred from physical interaction	24449906	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLD3 Protein Structure

CDC27

0
100
200
300
400
466 a.a.

Protein Preferred Names

Protein Names

DNA polymerase delta subunit 3

DNA polymerase delta subunit C

POLD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLD3	Q15054	PCNA	Homo sapiens	P12004	Anti Tag CoIP	16000169
Intra	POLD3	Q15054	POLD2	Homo sapiens	P49005	Anti Bait CoIP	16000169
Intra	POLD3	Q15054	POLD2	Homo sapiens	P49005	Y2H	16000169

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Chronic Fatigue Syndrome

Myalgic Encephalomyelitis	Postviral Fatigue Syndrome
Cfs	Myalgic Encephalitis
Encephalomyelitis, Myalgic	Chronic Fatigue
Fatigue Syndrome, Chronic	Benign Myalgic Encephalomyelitis
Akureyri	Akureyri Disease
Cfs - [Chronic Fatigue Syndrome]	Epidemic Neuromyasthenia
Myalgic Encephalomyelitis Syndrome	Me - [Myalgic Encephalomyelitis]
Pvfs - [Postviral Fatigue Syndrome]	Neuromyasthenia
Iceland Disease	Icelandic Disease

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10821	POLD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POLD3	VGNC	VGNC:33115
Macaca mulatta	POLD3	VGNC	VGNC:101381
Mus musculus	POLD3	MGD	MGI:1915217
Felis catus	POLD3	VGNC	VGNC:64283
Rattus norvegicus	POLD3	RGD	RGD:1312027
Canis familiaris	POLD3	VGNC	VGNC:44776

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