1. Gene
  2. POLD2 - DNA polymerase delta 2, accessory subunit Gene

POLD2 - DNA polymerase delta 2, accessory subunit Gene

Homo sapiens
Gene ID: 5425 | Gene type: protein coding

About POLD2

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,114,680-44,124,325 (from NCBI)

This gene has 68 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in heart (RPKM 20.0), ovary (RPKM 19.1) and 25 other tissues.

Summary

This gene encodes the 50-kDa catalytic subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA Polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

POLD2 Products(3)

mRNA Protein Name
NM_001127218.3 NP_001120690.1 DNA polymerase delta subunit 2
NM_001256879.2 NP_001243808.1 DNA polymerase delta subunit 2
NM_006230.4 NP_006221.3 DNA polymerase delta subunit 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12403614 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA biosynthetic process IDA
IDA: Inferred from direct assay
11595739 GOA
involved in DNA-templated DNA replication IDA
IDA: Inferred from direct assay
20334433 GOA
involved in error-prone translesion synthesis IDA
IDA: Inferred from direct assay
24449906 GOA
Cellular Component GO Annotation Evidence Reference Source
part of delta DNA polymerase complex IDA
IDA: Inferred from direct assay
11595739 GOA
part of delta DNA polymerase complex IPI
IPI: Inferred from physical interaction
12403614 GOA
part of zeta DNA polymerase complex IDA
IDA: Inferred from direct assay
22465957 GOA
part of zeta DNA polymerase complex IPI
IPI: Inferred from physical interaction
24449906 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLD2 Protein Structure

DNA_pol_E_B

DNA_pol_E_B: DNA polymerase alpha/epsilon subunit B (196 - 411)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

DNA polymerase delta subunit 2

DAN polymerase delta 2, accessory subunit

POLD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
POLD2 P49005 POLD1 Homo sapiens P28340 31449058
Intra
POLD2 P49005 POLD1 Homo sapiens P28340 33961781
Intra
POLD2 P49005 POLD1 Homo sapiens P28340 31449058
Intra
POLD2 P49005 POLD1 Homo sapiens P28340 28514442
Intra
POLD2 P49005 POLD1 Homo sapiens P28340 12403614
Intra
POLD2 P49005 POLD1 Homo sapiens P28340 16510448
Intra
POLD2 P49005 POLD3 Homo sapiens Q15054 31449058
Intra
POLD2 P49005 POLD3 Homo sapiens Q15054 16510448
Intra
POLD2 P49005 POLD3 Homo sapiens Q15054
Y2H
16000169
Intra
POLD2 P49005 POLD3 Homo sapiens Q15054 33961781
Intra
POLD2 P49005 POLD3 Homo sapiens Q15054 31449058
Intra
POLD2 P49005 POLD3 Homo sapiens Q15054 28514442
Intra
POLD2 P49005 POLD4 Homo sapiens Q9HCU8 33961781
Intra
POLD2 P49005 POLD4 Homo sapiens Q9HCU8 28514442
Intra
POLD2 P49005 POLD4 Homo sapiens Q9HCU8
Y2H
16510448
Intra
POLD2 P49005 POLD4 Homo sapiens Q9HCU8 16510448
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta POLD2 VGNC VGNC:76203
Bos taurus POLD2 VGNC VGNC:33114
Felis catus POLD2 VGNC VGNC:68937
Mus musculus POLD2 MGD MGI:1097163
Canis familiaris POLD2 VGNC VGNC:44775
Rattus norvegicus POLD2 RGD RGD:1304954