Nod1 - nucleotide-binding oligomerization domain containing 1 Gene

Mus musculus

Also known as Card4; Nlrc1; C230079P11; F830007N14Rik

Gene ID: 107607 | Gene type: protein coding

About Nod1

Chromosome 6: 54,900,934-54,949,597 reverse strand.GRCm39:CM000999.3

This gene has 6 transcripts (splice variants), 201 orthologues, 22 paralogues and is associated with 6 phenotypes. Broad expression in lung adult (RPKM 28.6), spleen adult (RPKM 22.7) and 19 other tissues.

Summary

Predicted to enable CARD domain binding activity; pattern recognition receptor activity; and protein homodimerization activity. Involved in positive regulation of dendritic cell antigen processing and presentation. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and positive regulation of xenophagy. Located in phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; olfactory epithelium; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nod1 Products(4)

mRNA	Protein	Name
NM_172729.3	NP_766317.1	nucleotide-binding oligomerization domain-containing protein 1
NM_001171007.1	NP_001164478.1	nucleotide-binding oligomerization domain-containing protein 1
NM_001171007.1	NP_001164478.1	nucleotide-binding oligomerization domain-containing protein 1
NM_172729.3	NP_766317.1	nucleotide-binding oligomerization domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	18261938	MGI
enables peptidoglycan binding	IDA IDA: Inferred from direct assay	16211083	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19898471	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of JNK cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within defense response to Gram-positive bacterium	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	18261938	MGI
acts upstream of interleukin-6 production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18261938	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	18261938	MGI
involved in nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA IDA: Inferred from direct assay	27007849	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	19898471	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of dendritic cell antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	20008287	MGI
acts upstream of or within positive regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18261938	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	18261938	MGI
acts upstream of or within positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	18261938	MGI
acts upstream of or within positive regulation of xenophagy	IMP IMP: Inferred from mutant phenotype	22033934	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	27007849	MGI
acts upstream of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	18261938	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	18261938	MGI
acts upstream of xenophagy	IMP IMP: Inferred from mutant phenotype	22033934	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	31649195	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nod1 Protein Structure

NACHT

NOD2_WH

NLRC4_HD2

PPP1R42

LRR_RI

0
200
400
600
800
953 a.a.

Protein Preferred Names

Protein Names

nucleotide-binding oligomerization domain-containing protein 1

caspase recruitment domain 4

caspase recruitment domain-containing protein 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100691	NOD-IN-1	Inhibitor	99.56%	Unkown
HY-18639	Nodinitib-1	Inhibitor	99.94%	Unkown
HY-170447	NOD1 antagonist-2	Antagonist	/	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown
HY-168024	NOD1/2-IN-1	Inhibitor	/	Unkown
HY-159965	NOD1-RIPK2-IN-1	Inhibitor	/	Unkown
HY-168023	NOD1-IN-1	Inhibitor	/	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nod1	NCBI	NCBI:10392

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