NOD1 - nucleotide binding oligomerization domain containing 1 Gene

Homo sapiens

Also known as CARD4; NLRC1; CLR7.1

Gene ID: 10392 | Gene type: protein coding

About NOD1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,424,527-30,478,784 (from NCBI)

This gene has 8 transcripts (splice variants), 201 orthologues and 20 paralogues. Ubiquitous expression in lung (RPKM 5.7), spleen (RPKM 4.5) and 24 other tissues.

Summary

This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds Bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic Infection. Major structural features of this protein include an N-terminal Caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]

NOD1 Products(35)

mRNA	Protein	Name
XR_926910.2
XM_047419766.1	XP_047275722.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X6
NM_001354849.2	NP_001341778.1	nucleotide-binding oligomerization domain-containing protein 1 isoform 2
XM_047419769.1	XP_047275725.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X10
XM_005249572.1	XP_005249629.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_006715633.3	XP_006715696.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419763.1	XP_047275719.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X4
XM_047419757.1	XP_047275713.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419767.1	XP_047275723.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_011515087.2	XP_011513389.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X8
XM_047419758.1	XP_047275714.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515083.2	XP_011513385.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_047419764.1	XP_047275720.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X5
NM_006092.4	NP_006083.1	nucleotide-binding oligomerization domain-containing protein 1 isoform 1
XM_047419754.1	XP_047275710.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XR_001744530.2
XM_047419752.1	XP_047275708.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_005249576.1	XP_005249633.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X11
XM_005249568.2	XP_005249625.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419760.1	XP_047275716.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419753.1	XP_047275709.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_011515085.2	XP_011513387.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419768.1	XP_047275724.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X7
XM_047419770.1	XP_047275726.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X12
XM_047419759.1	XP_047275715.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515079.1	XP_011513381.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419755.1	XP_047275711.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419756.1	XP_047275712.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515088.3	XP_011513390.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X9
XR_007059981.1
XM_011515084.2	XP_011513386.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419765.1	XP_047275721.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419761.1	XP_047275717.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419762.1	XP_047275718.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X4
NR_149002.2

NOD1 Protein Structure

CARD

NACHT

LRR_6

0
200
400
600
800
953 a.a.

Protein Preferred Names

Protein Names

nucleotide-binding oligomerization domain-containing protein 1

NLR family, CARD domain containing 1	caspase recruitment domain family, member 4
caspase recruitment domain-containing protein 4	nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1

Related Diseases

Diseases

Alias

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Chlamydia

Chlamydial Infection	Chlamydia Trachomatis Infectious Disease
Chlamydial Disease	Chlamydia Infections

Lymphoproliferative Syndrome, X-Linked, 2

XLP2	Xiap Deficiency
X-Linked Lymphoproliferative Syndrome 2	X-Linked Lymphoproliferative Disease Due To Xiap Deficiency
Xiap-Related Lymphoproliferative Disease, X-Linked	X-Linked Lymphoproliferative Syndrome Type 2
Xiap Deficiency Syndrome

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Enteritis, Granulomatous	Crohn'S Disease Of Colon
Granulomatous Colitis	Colitis, Granulomatous
Crohn'S Enteritis	Enteritis, Regional
Enteritis	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Colitis

Blau Syndrome

Arthrocutaneouveal Granulomatosis	Jabs Syndrome
BLAUS	Sarcoidosis, Early-Onset
Acug	Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial
Eos	Granulomatosis, Familial Juvenile Systemic
Granulomatosis, Familial, Blau Type	Familial Juvenile Systemic Granulomatosis
Early Onset Sarcoidosis	Synovitis Granulomatous With Uveitis And Cranial Neuropathies
Early-Onset Sarcoidosis	Familial Granulomatosis, Blau Type
Pediatric Granulomatous Arthritis	Familial Granulomatosis Blau Type
Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis	Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Salmonellosis

Salmonella Infections

Salmonella Infection

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Duodenal Ulcer

Stress Ulcer	Curling Ulcer
Stress Ulcer Of Stomach	Curling'S Ulcers
Duodenal Ulcer Disease	Duodenal Ulcers
Duodenal Peptic Ulcer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100691	NOD-IN-1	Inhibitor	99.56%	Unkown
HY-18639	Nodinitib-1	Inhibitor	99.86%	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown
HY-168024	NOD1/2-IN-1	Inhibitor	/	Unkown
HY-168023	NOD1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NOD1	RGD	RGD:1562269
Mus musculus	NOD1	MGD	MGI:1341839
Canis familiaris	NOD1	VGNC	VGNC:43877
Bos taurus	NOD1	VGNC	VGNC:32150
Macaca mulatta	NOD1	VGNC	VGNC:75185
Felis catus	NOD1	VGNC	VGNC:63849
Others	NOD1	NCBI

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