2. Gene
  3. NOD1 - nucleotide binding oligomerization domain containing 1 Gene

NOD1 - nucleotide binding oligomerization domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CARD4; NLRC1; CLR7.1

Gene ID: 10392 | Gene type: protein coding

About NOD1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,424,527-30,478,784 (from NCBI)

This gene has 8 transcripts (splice variants), 201 orthologues and 20 paralogues. Ubiquitous expression in lung (RPKM 5.7), spleen (RPKM 4.5) and 24 other tissues.

Summary

This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds Bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic Infection. Major structural features of this protein include an N-terminal Caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]

NOD1 Products(35)

mRNA Protein Name
XR_926910.2
XM_047419766.1 XP_047275722.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
NM_001354849.2 NP_001341778.1 nucleotide-binding oligomerization domain-containing protein 1 isoform 2
XM_047419769.1 XP_047275725.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X10
XM_005249572.1 XP_005249629.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_006715633.3 XP_006715696.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419763.1 XP_047275719.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X4
XM_047419757.1 XP_047275713.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419767.1 XP_047275723.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_011515087.2 XP_011513389.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X8
XM_047419758.1 XP_047275714.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515083.2 XP_011513385.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_047419764.1 XP_047275720.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X5
NM_006092.4 NP_006083.1 nucleotide-binding oligomerization domain-containing protein 1 isoform 1
XM_047419754.1 XP_047275710.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XR_001744530.2
XM_047419752.1 XP_047275708.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_005249576.1 XP_005249633.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X11
XM_005249568.2 XP_005249625.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419760.1 XP_047275716.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419753.1 XP_047275709.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X2
XM_011515085.2 XP_011513387.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419768.1 XP_047275724.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X7
XM_047419770.1 XP_047275726.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X12
XM_047419759.1 XP_047275715.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515079.1 XP_011513381.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1
XM_047419755.1 XP_047275711.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419756.1 XP_047275712.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_011515088.3 XP_011513390.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X9
XR_007059981.1
XM_011515084.2 XP_011513386.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419765.1 XP_047275721.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X6
XM_047419761.1 XP_047275717.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X3
XM_047419762.1 XP_047275718.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X4
NR_149002.2

NOD1 Protein Structure

CARD

CARD: Caspase recruitment domain (21 - 98)

NACHT

NACHT: NACHT domain (197 - 367)

LRR_6

LRR_6: Leucine Rich repeat (728 - 749)

LRR_6

LRR_6: Leucine Rich repeat (783 - 805)

LRR_6

LRR_6: Leucine Rich repeat (820 - 834)

LRR_6

LRR_6: Leucine Rich repeat (840 - 861)

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  • 953 a.a.
Protein Preferred Names Protein Names

nucleotide-binding oligomerization domain-containing protein 1

NLR family, CARD domain containing 1

caspase recruitment domain family, member 4

caspase recruitment domain-containing protein 4

nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1

NOD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NOD1 Q9Y239 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
NOD1 Q9Y239 RIPK2 Homo sapiens O43353
Lumier
37398436
Intra
NOD1 Q9Y239 RIPK2 Homo sapiens O43353
Anti Tag CoIP
17054981
Intra
NOD1 Q9Y239 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
NOD1 Q9Y239 PAK1 Homo sapiens Q13153
Validated Y2H
32814053
Intra
NOD1 Q9Y239 PAK1 Homo sapiens Q13153
Y2H Pooling
32814053
Intra
NOD1 Q9Y239 PAK1 Homo sapiens Q13153
Y2H Array
32814053
Intra
NOD1 Q9Y239 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra
NOD1 Q9Y239 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra
NOD1 Q9Y239 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra
NOD1 Q9Y239 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra
NOD1 Q9Y239 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra
NOD1 Q9Y239 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra
NOD1 Q9Y239 SUGT1 Homo sapiens Q9Y2Z0
Anti Tag CoIP
17420470
Intra
NOD1 Q9Y239 SUGT1 Homo sapiens Q9Y2Z0
Anti Tag CoIP
23935490
Intra
NOD1 Q9Y239 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
NOD1 Q9Y239 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
NOD1 Q9Y239 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
NOD1 Q9Y239 GFAP Homo sapiens P14136
Validated Y2H
32814053
Cross
NOD1 Q9Y239 sspH2 Salmonella typhimurium A0A0H3NF38
Anti Tag CoIP
23935490
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To

Legionella

Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease

Legionellosis

Legionaire Disease, Susceptibility To

Legionnaires Pneumonia
Chlamydia

Chlamydial Infection

Chlamydia Trachomatis Infectious Disease

Chlamydial Disease

Chlamydia Infections
Lymphoproliferative Syndrome, X-Linked, 2

XLP2

Xiap Deficiency

X-Linked Lymphoproliferative Syndrome 2

X-Linked Lymphoproliferative Disease Due To Xiap Deficiency

Xiap-Related Lymphoproliferative Disease, X-Linked

X-Linked Lymphoproliferative Syndrome Type 2

Xiap Deficiency Syndrome
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Enteritis, Granulomatous

Crohn'S Disease Of Colon

Granulomatous Colitis

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Enteritis

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Legionellosis

Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection
Colitis
Blau Syndrome

Arthrocutaneouveal Granulomatosis

Jabs Syndrome

BLAUS

Sarcoidosis, Early-Onset

Acug

Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial

Eos

Granulomatosis, Familial Juvenile Systemic

Granulomatosis, Familial, Blau Type

Familial Juvenile Systemic Granulomatosis

Early Onset Sarcoidosis

Synovitis Granulomatous With Uveitis And Cranial Neuropathies

Early-Onset Sarcoidosis

Familial Granulomatosis, Blau Type

Pediatric Granulomatous Arthritis

Familial Granulomatosis Blau Type

Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis

Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder
Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux
Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1

IBD1

Crohn Disease-Associated Growth Failure

Crohn Disease

Regional Enteritis

Ulcerative Colitis

Crohn Disease-Associated Growth Failure, Susceptibility To

Inflammatory Bowel Disease 1, Crohn Disease

Bowel Disease, Inflammatory, Type 1
Salmonellosis

Salmonella Infections

Salmonella Infection
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Duodenal Ulcer

Stress Ulcer

Curling Ulcer

Stress Ulcer Of Stomach

Curling'S Ulcers

Duodenal Ulcer Disease

Duodenal Ulcers

Duodenal Peptic Ulcer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100691 NOD-IN-1 Inhibitor 99.56% Unkown
HY-18639 Nodinitib-1 Inhibitor 99.94% Unkown
HY-163274 NOD1 antagonist-1 Antagonist / Unkown
HY-168024 NOD1/2-IN-1 Inhibitor / Unkown
HY-146034 NOD1/2 antagonist-1 Antagonist / Unkown
HY-159965 NOD1-RIPK2-IN-1 Inhibitor / Unkown
HY-168023 NOD1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NOD1 RGD RGD:1562269
Mus musculus NOD1 MGD MGI:1341839
Canis familiaris NOD1 VGNC VGNC:43877
Bos taurus NOD1 VGNC VGNC:32150
Macaca mulatta NOD1 VGNC VGNC:75185
Felis catus NOD1 VGNC VGNC:63849
Others NOD1 NCBI