NOD1 antagonist-2 

NOD1 antagonist-2 (compound 66) is an orally active selective antagonist of both human and mouse NOD1. NOD1 antagonist-2 (compound 66) antagonizes NOD1-induced NF-κB and MAPK pathways^[1].

NOD1 antagonist-2 (compound 66) demonstrates promising antagonistic activity against both h/mNOD1-induced NF-κB activation in HEK293 cells (IC₅₀ = 0.8 nM and 32 nM, respectively)^[1].
NOD1 antagonist-2 (compound 66, 0.1, 1 μM) markedly inhibits the increases in p-RIP2, p-p65, p-p38, and p-JNK of both THP-1 cells and mBMDMs, demonstrating its efficacy in modulating NOD1-induced signaling pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NOD1 antagonist-2 (compound 66, orally) inhibits the expression of inflammatory cytokines (IL-6, TNF-α) and chemokines (CXCL1, CXCL8) in immune and epithelial cells, as well as inflammatory cytokines (KC, IL-6) in a H. pylori-induced murine model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

560.38

C₂₁H₁₃Cl₂F₂N₃O₅S₂

CS(C1=CC=C(N=C(Cl)N(C2=CC(NS(=O)(C3=C(F)C=CC=C3F)=O)=C(Cl)C=C2)C4=O)C4=C1)(=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xinhua Liu, et al. Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection. J Med Chem. 2024 Dec 26;67(24):22145-22167.