Ankrd1 - ankyrin repeat domain 1 (cardiac muscle) Gene

Mus musculus

Also known as Alrp; CARP; Crap; MARP1

Gene ID: 107765 | Gene type: protein coding

About Ankrd1

Summary

Enables titin binding activity and transcription corepressor activity. Involved in cellular response to lipopolysaccharide and cellular response to xenobiotic stimulus. Acts upstream of or within protein kinase C signaling; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in I band and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; heart; male reproductive gland or organ; skeletal musculature; and somite. Human ortholog(s) of this gene implicated in congenital structural myopathy; dilated cardiomyopathy; hypertrophic cardiomyopathy; nemaline myopathy; and spinal muscular atrophy. Orthologous to human ANKRD1 (ankyrin repeat domain 1). [provided by Alliance of Genome Resources, Apr 2022]

Ankrd1 Products(1)

mRNA	Protein	Name
NM_013468.3	NP_038496.2	ankyrin repeat domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14741210	MGI
enables titin binding	IPI IPI: Inferred from physical interaction	18310072	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	9043061	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	17239933	MGI
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	17239933	MGI
acts upstream of or within phospholipase C/protein kinase C signal transduction	IGI IGI: Inferred from genetic interaction	27353086	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9043061	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in I band	IDA IDA: Inferred from direct assay	11309420	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9382869	MGI
located in myofibril	IDA IDA: Inferred from direct assay	18310072	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9382869	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	27353086	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9043061	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ankyrin repeat domain-containing protein 1

ankyrin-like repeat protein	cardiac ankyrin repeat protein
cardiac responsive adriamycin protein

Ankrd1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ankrd1	Q9CR42	Ncl	Mus musculus	P09405	Anti Bait CoIP	24515436
Intra	Ankrd1	Q9CR42	Ncl	Mus musculus	P09405	Y2H	24515436
Intra	Ankrd1	Q9CR42	Ncl	Mus musculus	P09405	Anti Tag CoIP	24515436
Intra	Ankrd1	Q9CR42	Ncl	Mus musculus	P09405	IF	24515436

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00712	ANKRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ankrd1	NCBI	NCBI:27063

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