SEC24A - SEC24 homolog A, COPII coat complex component Gene

Homo sapiens

Gene ID: 10802 | Gene type: protein coding

About SEC24A

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,648,382-134,727,909 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in small intestine (RPKM 10.1), duodenum (RPKM 10.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SEC24A Products(2)

mRNA	Protein	Name
NM_001252231.2	NP_001239160.1	protein transport protein Sec24A isoform 2
NM_021982.3	NP_068817.1	protein transport protein Sec24A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17499046	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18843296	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in COPII-coated vesicle cargo loading	IDA IDA: Inferred from direct assay	17499046	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	20427317	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COPII vesicle coat	IDA IDA: Inferred from direct assay	17499046	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC24A Protein Structure

zf-Sec23_Sec24

Sec23_trunk

Sec23_BS

Sec23_helical

Gelsolin

0
200
400
600
800
1000
1093 a.a.

Protein Preferred Names

Protein Names

protein transport protein Sec24A

SEC24 family, member A

Related Diseases

Diseases

Alias

Ceroid Lipofuscinosis, Neuronal, 8

Neuronal Ceroid Lipofuscinosis 8	CLN8
Cln8 Disease	Epilepsy Mental Deterioration Finnish Type
Northern Epilepsy	Cln8 Disease, Epmr
Cln8 Disease, Northern Epilepsy Variant	Cln8 Disease, Late Infantile
Ceroid Lipofuscinosis Neuronal 8	Ncl, Northern Epilepsy Variant
Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant	Progressive Epilepsy - Intellectual Disability, Finnish Type
Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type	Turkish Variant Late Infantile Ncl
Ceroid Lipofuscinosis, Neuronal 8	Lipofuscinosis, Ceroid, Neuronal, Type 8
Northern Epilepsy Syndrome

Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome	CLSD
Cranio-Lenticulo-Sutural Dysplasia	Cranio-Lenticulo-Sutural Dysplasia, Clsd

Anemia, Congenital Dyserythropoietic, Type Ii

Congenital Dyserythropoietic Anemia Type Ii	CDAN2
Cda Ii	Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test
Cda Type Ii	Congenital Dyserythropoietic Anemia Type 2
Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test	Sec23b-Cdg
Congenital Dyserythropoietic Anemia, Type Ii	Dyserythropoietic Anemia, Hempas Type
Hempas	Cda Type 2
Dyserythropoietic Anemia, Congenital, Type Ii	Cda, Type Ii
Congenital Dyserythropoietic Anaemia Type 2	Congenital Dyserythropoietic Anaemia Type Ii
Anemia, Dyserythropoietic, Congenital Type 2	Hempas Anemia
Dyserythropoietic Anemia, Congenital Type 2	Anemia, Congenital Dyserythropoietic, 2
Dyserythropoietic Anemia Hempas Type	Anemia, Dyserythropoietic Congenital, Type Ii
Anemia, Dyserythropoietic, Congenital, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12615	SEC24A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SEC24A	MGD	MGI:1924621
Bos taurus	SEC24A	VGNC	VGNC:34413
Rattus norvegicus	SEC24A	RGD	RGD:1309451
Felis catus	SEC24A	VGNC	VGNC:64967
Macaca mulatta	SEC24A	VGNC	VGNC:77152
Canis familiaris	SEC24A	VGNC	VGNC:45972
Others	SEC24A	NCBI

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