CPLX2 - complexin 2 Gene

Homo sapiens

Also known as CPX2; Hfb1; 921-L; CPX-2

Gene ID: 10814 | Gene type: protein coding

About CPLX2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,796,533-175,884,021 (from NCBI)

This gene has 10 transcripts (splice variants), 115 orthologues and 3 paralogues. Biased expression in brain (RPKM 63.0) and adrenal (RPKM 12.1).

Summary

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CPLX2 Products(2)

mRNA	Protein	Name
NM_001008220.2	NP_001008221.1	complexin-2
NM_006650.4	NP_006641.1	complexin-2

CPLX2 Protein Structure

Synaphin

0
100
134 a.a.

Protein Preferred Names

Protein Names

complexin-2

CPX II

Recombinant CPLX2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76282	CPLX2/Complexin-2 Protein, Human (His)	Q6PUV4 (D2-K134)	≥95%

Related Diseases

Diseases

Alias

Lacrimal Gland Carcinoma

Lacrimal Gland Cancer	Carcinoma Of The Lacrimal Gland
Malignant Neoplasm Of Lacrimal Gland	Malignant Tumour Of Lacrimal Gland
Neoplasm Of Lacrimal Gland	Tumor Of The Lacrimal Gland
Malignant Tumor Of Lacrimal Gland

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Epilepsy, Familial Temporal Lobe, 7

Familial Temporal Lobe Epilepsy 7	ETL7
Epilepsy, Temporal Lobe, Familial, Type 7

Lacrimal Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lacrimal Gland

Lacrimal Gland Adenocarcinoma

Adenocarcinoma Of Lacrimal Gland

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03098	CPLX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CPLX2	VGNC	VGNC:27652
Canis familiaris	CPLX2	VGNC	VGNC:39556
Mus musculus	CPLX2	MGD	MGI:104726
Rattus norvegicus	CPLX2	RGD	RGD:70945
Felis catus	CPLX2	VGNC	VGNC:102182
Others	CPLX2	NCBI

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