2. Gene
  3. MYG1 - MYG1 exonuclease Gene

MYG1 - MYG1 exonuclease Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MYG; Gamm1; MST024; MSTP024; C12orf10

Gene ID: 60314 | Gene type: protein coding

About MYG1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,299,695-53,307,177 (from NCBI)

This gene has 10 transcripts (splice variants) and 204 orthologues. Broad expression in testis (RPKM 46.7), ovary (RPKM 22.5) and 25 other tissues.

Summary

Predicted to enable nuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Predicted to act upstream of or within locomotory exploration behavior. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MYG1 Products(1)

mRNA Protein Name
NM_021640.4 NP_067653.4 MYG1 exonuclease precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
19014353 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19014353 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYG1 Protein Structure

UPF0160

UPF0160: Uncharacterised protein family (UPF0160) (46 - 366)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

MYG1 exonuclease

UPF0160 protein MYG1, mitochondrial

MYG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MYG1 Q9HB07 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra
MYG1 Q9HB07 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
MYG1 Q9HB07 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
MYG1 Q9HB07 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
MYG1 Q9HB07 PELO Homo sapiens Q9BRX2
Validated Y2H
32814053
Intra
MYG1 Q9HB07 PELO Homo sapiens Q9BRX2
Y2H Array
32814053
Intra
MYG1 Q9HB07 PELO Homo sapiens Q9BRX2
Y2H Pooling
32814053
Intra
MYG1 Q9HB07 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
MYG1 Q9HB07 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 CMTM5 Homo sapiens Q96DZ9-2
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 CMTM5 Homo sapiens Q96DZ9-2
Y2H Array
32296183
Intra
MYG1 Q9HB07 AP1B1 Homo sapiens Q10567-3
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 AP1B1 Homo sapiens Q10567-3
Y2H Array
32296183
Intra
MYG1 Q9HB07 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
MYG1 Q9HB07 SYNGR1 Homo sapiens O43759-2
Validated Y2H
32296183
Intra
MYG1 Q9HB07 SYNGR1 Homo sapiens O43759-2
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 SYNGR1 Homo sapiens O43759-2
Y2H Array
32296183
Intra
MYG1 Q9HB07 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Array
32296183
Intra
MYG1 Q9HB07 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 DESI2 Homo sapiens Q9BSY9
Y2H Array
32296183
Intra
MYG1 Q9HB07 DESI2 Homo sapiens Q9BSY9
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
Intra
MYG1 Q9HB07 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
MYG1 Q9HB07 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 TIMM17B Homo sapiens O60830
Y2H Array
32296183
Intra
MYG1 Q9HB07 TIMM17B Homo sapiens O60830
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 CMTM5 Homo sapiens Q96DZ9
Y2H Array
25416956
Intra
MYG1 Q9HB07 CMTM5 Homo sapiens Q96DZ9
Validated Y2H
25416956
Intra
MYG1 Q9HB07 CPLX2 Homo sapiens Q6PUV4
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 CPLX2 Homo sapiens Q6PUV4
Y2H Array
32296183
Intra
MYG1 Q9HB07 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 YIF1A Homo sapiens O95070
Y2H Array
32296183
Intra
MYG1 Q9HB07 METTL9 Homo sapiens Q9H1A3
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 METTL9 Homo sapiens Q9H1A3
Y2H Array
32296183
Intra
MYG1 Q9HB07 SFT2D1 Homo sapiens Q8WV19
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 SFT2D1 Homo sapiens Q8WV19
Y2H Array
32296183
Intra
MYG1 Q9HB07 MTNAP1 Homo sapiens Q9BSJ5
Validated Y2H
32814053
Intra
MYG1 Q9HB07 MTNAP1 Homo sapiens Q9BSJ5
Y2H Array
32814053
Intra
MYG1 Q9HB07 MTNAP1 Homo sapiens Q9BSJ5
Y2H Pooling
32814053
Intra
MYG1 Q9HB07 EEF1G Homo sapiens P26641
Y2H Array
32814053
Intra
MYG1 Q9HB07 EEF1G Homo sapiens P26641
Validated Y2H
32814053
Intra
MYG1 Q9HB07 EEF1G Homo sapiens P26641
Y2H Pooling
32814053
Intra
MYG1 Q9HB07 APOA5 Homo sapiens Q6Q788
Y2H Array
32296183
Intra
MYG1 Q9HB07 APOA5 Homo sapiens Q6Q788
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 SLC17A9 Homo sapiens Q9BYT1
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 SLC17A9 Homo sapiens Q9BYT1
Y2H Array
32296183
Intra
MYG1 Q9HB07 ARL6IP1 Homo sapiens Q15041
Y2H Array
25416956
Intra
MYG1 Q9HB07 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
Intra
MYG1 Q9HB07 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 DCAF10 Homo sapiens Q5QP82
Anti Tag CoIP
33961781
Intra
MYG1 Q9HB07 PLIN3 Homo sapiens O60664
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 PLIN3 Homo sapiens O60664
Y2H Array
32296183
Intra
MYG1 Q9HB07 MAN1C1 Homo sapiens Q9NR34
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 MAN1C1 Homo sapiens Q9NR34
Y2H Array
32296183
Intra
MYG1 Q9HB07 MAN1C1 Homo sapiens Q9NR34
Validated Y2H
32296183
Intra
MYG1 Q9HB07 AGTRAP Homo sapiens Q6RW13
Y2H Array
25416956
Intra
MYG1 Q9HB07 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Intra
MYG1 Q9HB07 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Intra
MYG1 Q9HB07 RBM11 Homo sapiens P57052
Y2H Array
32814053
Intra
MYG1 Q9HB07 RBM11 Homo sapiens P57052
Y2H Pooling
32814053
Intra
MYG1 Q9HB07 RBM11 Homo sapiens P57052
Validated Y2H
32814053
Intra
MYG1 Q9HB07 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
MYG1 Q9HB07 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
MYG1 Q9HB07 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
MYG1 Q9HB07 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
MYG1 Q9HB07 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 BSND Homo sapiens Q8WZ55
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 BSND Homo sapiens Q8WZ55
Y2H Array
32296183
Intra
MYG1 Q9HB07 SYP Homo sapiens P08247
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 SYP Homo sapiens P08247
Y2H Array
32296183
Intra
MYG1 Q9HB07 ROM1 Homo sapiens Q03395
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 ROM1 Homo sapiens Q03395
Y2H Array
32296183
Intra
MYG1 Q9HB07 MAL2 Homo sapiens Q969L2
Y2H Prey Pooling
32296183
Intra
MYG1 Q9HB07 MAL2 Homo sapiens Q969L2
Y2H Array
32296183
Intra
MYG1 Q9HB07 TMEM239 Homo sapiens Q8WW34
Y2H Array
25416956
Intra
MYG1 Q9HB07 TMEM239 Homo sapiens Q8WW34
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nemaline Myopathy 4

Cap Myopathy 2

NEM4

Nemaline Myopathy 4, Autosomal Dominant

Nemaline Myopathy, Type 4

CAPM2

Cap Disease

Cap Myopathy Tpm2-Related

Tpm2-Related Nemaline Myopathy

Tpm2-Related Cap Myopathy

Myopathy, Nemaline, Type 4

Cap Myopathy
Dracunculiasis

Guinea Worm Disease

Dracontiasis

Dracunculosis

Infection By Dracunculus Medinensis

Gwd

Guinea Worm Infection

Parasitic Infection Caused By Dracunculus Medinensis

Medina Worm Disease

Medinensis

Medina Worm Infestation

Dracunculus Medinensis Infestation

Guinea Worm Infestation
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

Vitiligo

VAMAS1

Slev1

Vtlg

Systemic Lupus Erythematosus, Vitiligo-Related

Vitiligo-Associated Multiple Autoimmune Disease 1

Systemic Lupus Erythematosus Vitiligo-Related
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08894 MYG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MYG1 VGNC VGNC:49228
Mus musculus MYG1 MGD MGI:1929864
Macaca mulatta MYG1 VGNC VGNC:70338
Bos taurus MYG1 VGNC VGNC:49159
Rattus norvegicus MYG1 RGD RGD:1359237