2. Gene
  3. CCL27 - C-C motif chemokine ligand 27 Gene

CCL27 - C-C motif chemokine ligand 27 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27

Gene ID: 10850 | Gene type: protein coding

About CCL27

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,661,890-34,662,657 (from NCBI)

This gene has 2 transcripts (splice variants), 106 orthologues and 1 paralogue. Biased expression in skin (RPKM 77.8), spleen (RPKM 8.8) and 11 other tissues.

Summary

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to Chemokine Receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

CCL27 Products(1)

mRNA Protein Name
NM_006664.4 NP_006655.1 C-C motif chemokine 27 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables CCR3 chemokine receptor binding IPI
IPI: Inferred from physical interaction
12538707 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28381538 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
19109182 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
19109182 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL27 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (31 - 89)

  • 0
  • 100
  • 112 a.a.
Protein Preferred Names Protein Names

C-C motif chemokine 27

CC chemokine ILC

CCL27 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CCL27 Q9Y4X3 CCL5 Homo sapiens P13501
Filter Binding
28381538
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL27 Proteins

Cat. No. Product Name Accession Purity
HY-P7767 CTACK/CCL27 Protein, Human Q9Y4X3 (F25-G112) ≥95%
HY-P7767A CTACK/CCL27 Protein, Human (His) Q9Y4X3 (F25-G112) ≥95%

Related Diseases

Diseases Alias
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Molluscum Contagiosum

Water Warts

Molluscum Verrucosum
Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Hypophosphatasia

Phosphoethanolaminuria

Childhood Hypophosphatasia

Deficiency Of Alkaline Phosphatase

Hypophospatasia, Childhood

Hypophosphatasia Mild

Phosphoethanol-Aminuria

Rathburn Disease

Hpp

Rathbun Disease

Hypophosphatasia, Childhood

Infantile Hypophosphatasia
Chancroid

Ulcus Molle, Skin

Chancroids

Bubo Due To Haemophilus Ducreyi

Soft Chancre

Ulcus Molle
Psoriasis
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Irritant Dermatitis

Irritant Contact Dermatitis

Primary Irritant Dermatitis

Dermatitis, Irritant

Contact Dermatitis, Irritant

Irritant Contact Eczema

Icd - [Irritant Contact Dermatitis]

Irritant Contact Dermatitis, Unspecified Cause

Non-Allergic Contact Dermatitis

Irritant Contact Eczema Due To Wet Work

Irritant Contact Dermatitis Due To Detergents

Irritant Contact Eczema Due To Solvents

Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants

Irritant Contact Eczema Due To Cosmetics Or Emollients

Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials

Irritant Contact Eczema Due To Plants Or Other Vegetable Matter

Irritant Contact Eczema Due To Foods

Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids

Irritant Contact Eczema Due To Saliva

Irritant Contact Eczema Due To Incontinence

Incontinence-Associated Dermatitis
Norwegian Scabies

Crusted Scabies

Seven Year Itch
Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02097 CCL27 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CCL27 VGNC VGNC:102906
Canis familiaris CCL27 VGNC VGNC:38889
Rattus norvegicus CCL27 RGD RGD:1304660
Macaca mulatta CCL27 VGNC VGNC:103246
Bos taurus CCL27 VGNC VGNC:26952
Mus musculus CCL27 NCBI
Others CCL27 NCBI