SPIN1 - spindlin 1 Gene

Homo sapiens

Also known as SPIN; TDRD24

Gene ID: 10927 | Gene type: protein coding

About SPIN1

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:88,388,444-88,478,694 (from NCBI)

This gene has 6 transcripts (splice variants), 271 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 40.9), brain (RPKM 36.4) and 25 other tissues.

Summary

Enables methylated histone binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of transcription, DNA-templated; and rRNA transcription. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SPIN1 Products(1)

mRNA	Protein	Name
NM_006717.3	NP_006708.2	spindlin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	21029866	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24589551	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	29061846	GOA
involved in positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	24589551	GOA
involved in rRNA transcription	IDA IDA: Inferred from direct assay	21960006	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	21960006	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29061846	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPIN1 Protein Structure

Spin-Ssty

0
100
200
262 a.a.

Protein Preferred Names

Protein Names

spindlin-1

ovarian cancer-related protein

Related Diseases

Diseases

Alias

Acquired Color Blindness

Acquired Color Vision Deficiencies	Acquired Color Vision Deficiency
Acquired Colour Blindness	Acquired Colour Vision Deficiencies
Acquired Colour Vision Deficiency

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125837A	MS31 trihydrochloride	Inhibitor	≥98.0%	Unkown
HY-RS13675	SPIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125837	MS31	Inhibitor	/	Unkown
HY-161068	hACE2/SP-IN-1	Inhibitor	/	Unkown
HY-163460	MS8535	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SPIN1	VGNC	VGNC:77859
Mus musculus	SPIN1	MGD	MGI:109242
Felis catus	SPIN1	VGNC	VGNC:102985
Rattus norvegicus	SPIN1	RGD	RGD:1306210
Bos taurus	SPIN1	VGNC	VGNC:35217
Canis familiaris	SPIN1	VGNC	VGNC:46742

Name
Email *

	Sorry, but the email address you supplied was invalid.