TOMM34 - translocase of outer mitochondrial membrane 34 Gene

Homo sapiens

Also known as TOM34; URCC3; HTOM34P

Gene ID: 10953 | Gene type: protein coding

About TOMM34

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,942,130-44,960,397 (from NCBI)

This gene has 1 transcript (splice variant), 122 orthologues and 18 paralogues. Broad expression in testis (RPKM 58.9), adrenal (RPKM 15.3) and 22 other tissues.

Summary

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]

TOMM34 Products(1)

mRNA	Protein	Name
NM_006809.5	NP_006800.2	mitochondrial import receptor subunit TOM34

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	9660753	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	9324309	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	9324309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOMM34 Protein Structure

TPR_11

TPR_1

TPR_11

TPR_2

0
100
200
309 a.a.

Protein Preferred Names

Protein Names

mitochondrial import receptor subunit TOM34

hTom34

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 3

Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3	COXPD3
Encephalomyopathy, Respiratory Failure, And Lactic Acidosis	Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis
Fatal Mitochondrial Disease Due To Coxpd3	Concentric Cardiomyopathy Hypotonia And Lactic Acidosis
Encephalomyopathy Respiratory Failure And Lactic Acidosis	Encephalomyopathy With Respiratory Failure And Lactic Acidosis
Combined Oxidative Phosphorylation Deficiency, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14881	TOMM34 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TOMM34	VGNC	VGNC:97837
Bos taurus	TOMM34	VGNC	VGNC:49135
Mus musculus	TOMM34	MGD	MGI:1914395
Rattus norvegicus	TOMM34	RGD	RGD:1309029
Felis catus	TOMM34	VGNC	VGNC:81251
Canis familiaris	TOMM34	VGNC	VGNC:49628

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