SERINC3 - serine incorporator 3 Gene

Homo sapiens

Also known as TDE; TDE1; AIGP1; TMS-1; DIFF33; SBBI99

Gene ID: 10955 | Gene type: protein coding

About SERINC3

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,496,221-44,522,070 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 33.6), testis (RPKM 32.1) and 25 other tissues.

Summary

Predicted to enable L-serine transmembrane transporter activity. Involved in defense response to virus; detection of virus; and innate immune response. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SERINC3 Products(2)

mRNA	Protein	Name
NM_006811.4	NP_006802.1	serine incorporator 3 precursor
NM_198941.3	NP_945179.1	serine incorporator 3 precursor

SERINC3 Protein Structure

Serinc

0
100
200
300
400
473 a.a.

Protein Preferred Names

Protein Names

serine incorporator 3

tumor differentially expressed protein 1

SERINC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SERINC3	Q13530	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SERINC3	Q13530	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SERINC3	Q13530	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	SERINC3	Q13530	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	SERINC3	Q13530	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	SERINC3	Q13530	PEX1	Homo sapiens	O43933	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spastic Paraplegia 50, Autosomal Recessive

Hereditary Spastic Paraplegia 50	SPG50
Ap-4 Deficiency Syndrome	Ap-4-Associated Hereditary Spastic Paraplegia
Adaptor Protein Complex 4 Deficiency	Cerebral Palsy, Spastic Quadriplegic, 3, Formerly
Cpsq3, Formerly	Autosomal Recessive Spastic Paraplegia 50
Cpsq3	Spastic Quadriplegic Cerebral Palsy 3
Ap-4 Deficiency	Ap-4-Associated Hsp
Paraplegia, Spastic, Autosomal Recessive, Type 50	Spastic Paraplegia-50, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12692	SERINC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SERINC3	RGD	RGD:1308390
Macaca mulatta	SERINC3	VGNC	VGNC:77222
Mus musculus	SERINC3	MGD	MGI:1349457
Canis familiaris	SERINC3	VGNC	VGNC:46021
Felis catus	SERINC3	VGNC	VGNC:65019
Bos taurus	SERINC3	VGNC	VGNC:34462

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