2. Gene
  3. F11 - coagulation factor XI Gene

F11 - coagulation factor XI Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as FXI; PTA; Cf11; 1600027G01Rik

Gene ID: 109821 | Gene type: protein coding

About F11

Summary

This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, Thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and Bacterial accumulation upon Infection with Listeria. [provided by RefSeq, Apr 2015]

F11 Products(2)

mRNA Protein Name
NM_001411665.1 NP_001398594.1 coagulation factor XI isoform 2
NM_028066.3 NP_082342.1 coagulation factor XI isoform 1 preproprotein
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
16533887 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coagulation factor XI

plasma thromboplastin antecedent

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162065 N6F11 Inducer 98.37% Unkown
HY-N0541 Pseudoginsenoside F11 99.87% Unkown
HY-N6650 Isotanshinone IIA ≥98.0% Unkown
HY-19606 Cytogenin Inhibitor / Unkown
HY-RS03478 CYP4F11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04625 F11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04626 F11R Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W472509 11-HETE Activator / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991124 Cenvacibart Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F11 NCBI NCBI:2160
Canis familiaris F11 NCBI NCBI:475623
Macaca fascicularis F11 NCBI NCBI:102143421
Leporidae F11 NCBI
Rattus norvegicus F11 NCBI NCBI:290757
Macaca mulatta F11 NCBI NCBI:702117