TRIM31 - tripartite motif containing 31 Gene

Homo sapiens

Also known as RNF; HCG1; HCGI; C6orf13

Gene ID: 11074 | Gene type: protein coding

About TRIM31

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,102,897-30,113,090 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 46 orthologues and 80 paralogues. Biased expression in colon (RPKM 26.2), urinary bladder (RPKM 20.1) and 5 other tissues.

Summary

This gene encodes a protein that functions as an E3 ubiquitin-protein Ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

TRIM31 Products(1)

mRNA	Protein	Name
NM_007028.5	NP_008959.3	E3 ubiquitin-protein ligase TRIM31

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	27929086	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	27992402	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	27992402	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	18248090	GOA
involved in negative regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	27929086	GOA
involved in negative regulation of viral entry into host cell	IMP IMP: Inferred from mutant phenotype	18248090	GOA
involved in negative regulation of viral transcription	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	27929086	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	27992402	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	27929086	GOA
involved in viral release from host cell	IMP IMP: Inferred from mutant phenotype	18248090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	27992402	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM31 Protein Structure

zf-C3HC4_4

zf-B_box

0
100
200
300
400
425 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM31

RING-type E3 ubiquitin transferase TRIM31

TRIM31 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM31	Q9BZY9	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	TRIM31	Q9BZY9	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	TRIM31	Q9BZY9	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	TRIM31	Q9BZY9	MAGEA1	Homo sapiens	P43355	Y2H Array	25416956
Intra	TRIM31	Q9BZY9	MAGEA1	Homo sapiens	P43355	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15036	TRIM31 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIM31	VGNC	VGNC:36327
Rattus norvegicus	TRIM31	RGD	RGD:1308607
Mus musculus	TRIM31	MGD	MGI:2385051

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