2. Gene
  3. DIDO1 - death inducer-obliterator 1 Gene

DIDO1 - death inducer-obliterator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8

Gene ID: 11083 | Gene type: protein coding

About DIDO1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,877,743-62,937,904 (from NCBI)

This gene has 7 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 4.7), spleen (RPKM 4.7) and 25 other tissues.

Summary

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan Animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced Apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in Apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]

DIDO1 Products(6)

mRNA Protein Name
NM_001193369.2 NP_001180298.1 death-inducer obliterator 1 isoform c
NM_001193370.2 NP_001180299.1 death-inducer obliterator 1 isoform b
NM_022105.5 NP_071388.2 death-inducer obliterator 1 isoform a
NM_033081.3 NP_149072.2 death-inducer obliterator 1 isoform c
NM_080796.4 NP_542986.1 death-inducer obliterator 1 isoform a
NM_080797.4 NP_542987.2 death-inducer obliterator 1 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24981860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIDO1 Protein Structure

PHD

PHD: PHD-finger (270 - 320)

TFIIS_M

TFIIS_M: Transcription factor S-II (TFIIS), central domain (667 - 777)

SPOC

SPOC: SPOC domain (1057 - 1163)

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  • 2240 a.a.
Protein Preferred Names Protein Names

death-inducer obliterator 1

death-associated transcription factor 1

DIDO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DIDO1 Q9BTC0 HCFC1 Homo sapiens P51610
Anti Tag CoIP
33961781
Intra
DIDO1 Q9BTC0 HCFC1 Homo sapiens P51610
TAP
24981860
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101111 PF-06840003 Inhibitor 99.87% Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03767 DIDO1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DIDO1 MGD MGI:1344352
Macaca mulatta DIDO1 VGNC VGNC:71736
Bos taurus DIDO1 VGNC VGNC:28064
Felis catus DIDO1 VGNC VGNC:80083
Rattus norvegicus DIDO1 RGD RGD:1311173
Canis familiaris DIDO1 VGNC VGNC:54296