PRSS23 - serine protease 23 Gene

Homo sapiens

Also known as SIG13; SPUVE; ZSIG13

Gene ID: 11098 | Gene type: protein coding

About PRSS23

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,791,071-86,952,910 (from NCBI)

This gene has 9 transcripts (splice variants), 176 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 19.0), urinary bladder (RPKM 17.9) and 24 other tissues.

Summary

This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

PRSS23 Products(3)

mRNA	Protein	Name
NM_001293179.2	NP_001280108.1	serine protease 23 precursor
NM_001293180.2	NP_001280109.1	serine protease 23 precursor
NM_007173.6	NP_009104.3	serine protease 23 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS23 Protein Structure

Trypsin

0
100
200
300
383 a.a.

Protein Preferred Names

Protein Names

serine protease 23

protease, serine 23

PRSS23 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRSS23	O95084	SEC11C	Homo sapiens	Q9BY50	Validated Y2H	32296183
Intra	PRSS23	O95084	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
Intra	PRSS23	O95084	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity	Retrolental Fibroplasia
EVR1	Criswick-Schepens Syndrome
Rop	Exudative Vitreoretinopathy, Familial, Autosomal Dominant
Fevr, Autosomal Dominant	Premature Retinopathy
Vitreoretinopathy, Exudative 1	Autosomal Dominant Familial Exudative Vitreoretinopathy
Fevr	Vitreoretinopathy, Exudative, Type 1
Retinopathy Of Prematurity Nos	Rlf- [Retrolental Fibroplasia]
Rop - [Retinopathy Of Prematurity]	Terry Syndrome

Coats Disease

Exudative Retinopathy	Retinal Telangiectasis
Coats' Disease	Leber Miliary Aneurysm
Coats' Syndrome	Congenital Retinal Telangiectasia

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Marginal Corneal Ulcer

Vascular Skin Disease

Skin Diseases, Vascular

Skin Vascular Disease

Keipert Syndrome

Nasodigitoacoustic Syndrome	KPTS
Nasodigitoacoustic Syndrome, Formerly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11251	PRSS23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRSS23	VGNC	VGNC:64397
Macaca mulatta	PRSS23	VGNC	VGNC:76253
Bos taurus	PRSS23	VGNC	VGNC:33416
Mus musculus	PRSS23	MGD	MGI:1923703
Rattus norvegicus	PRSS23	RGD	RGD:1359545
Canis familiaris	PRSS23	VGNC	VGNC:45065

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