2. Gene
  3. PKIG - cAMP-dependent protein kinase inhibitor gamma Gene

PKIG - cAMP-dependent protein kinase inhibitor gamma Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PKI-gamma

Gene ID: 11142 | Gene type: protein coding

About PKIG

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,531,875-44,619,037 (from NCBI)

This gene has 8 transcripts (splice variants), 173 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 51.1), urinary bladder (RPKM 28.8) and 24 other tissues.

Summary

This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PKIG Products(5)

mRNA Protein Name
NM_001281444.2 NP_001268373.1 cAMP-dependent protein kinase inhibitor gamma
NM_001281445.2 NP_001268374.1 cAMP-dependent protein kinase inhibitor gamma
NM_007066.5 NP_008997.1 cAMP-dependent protein kinase inhibitor gamma
NM_181804.3 NP_861520.1 cAMP-dependent protein kinase inhibitor gamma
NM_181805.3 NP_861521.1 cAMP-dependent protein kinase inhibitor gamma
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKIG Protein Structure

PKI

PKI: cAMP-dependent protein kinase inhibitor (2 - 71)

  • 0
  • 76 a.a.
Protein Preferred Names Protein Names

cAMP-dependent protein kinase inhibitor gamma

protein kinase (cAMP-dependent, catalytic) inhibitor gamma

PKIG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PKIG Q9Y2B9 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra
PKIG Q9Y2B9 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra
PKIG Q9Y2B9 DYNLL2 Homo sapiens Q96FJ2
Y2H Array
32296183
Intra
PKIG Q9Y2B9 DYNLL2 Homo sapiens Q96FJ2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Theileriasis

Theileriosis

Infection By Theileria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10600 PKIG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PKIG RGD RGD:628775
Bos taurus PKIG VGNC VGNC:32942
Macaca mulatta PKIG VGNC VGNC:97118
Mus musculus PKIG MGD MGI:1343086