2. Gene
  3. DYNLL2 - dynein light chain LC8-type 2 Gene

DYNLL2 - dynein light chain LC8-type 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Dlc2; DNCL1B; RSPH22

Gene ID: 140735 | Gene type: protein coding

About DYNLL2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,083,419-58,095,542 (from NCBI)

This gene has 1 transcript (splice variant), 252 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 120.2), kidney (RPKM 90.1) and 25 other tissues.

Summary

Predicted to enable dynein intermediate chain binding activity and dynein LIGHT intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

DYNLL2 Products(1)

mRNA Protein Name
NM_080677.3 NP_542408.1 dynein light chain 2, cytoplasmic
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in 9+0 non-motile cilium IDA
IDA: Inferred from direct assay
29257953 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in cytoskeleton IDA
IDA: Inferred from direct assay
20921139 GOA
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22328512 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22328512 GOA
is active in postsynapse IDA
IDA: Inferred from direct assay
22328512 GOA
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
22328512 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLL2 Protein Structure

Dynein_light

Dynein_light: Dynein light chain type 1 (1 - 89)

  • 0
  • 89 a.a.
Protein Preferred Names Protein Names

dynein light chain 2, cytoplasmic

8 kDa dynein light chain b

DYNLL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra DYNLL2 Q96FJ2 REDIC1 Homo sapiens Q86WS4
Validated Y2H
25416956
Intra DYNLL2 Q96FJ2 REDIC1 Homo sapiens Q86WS4
Y2H Array
25416956
Intra DYNLL2 Q96FJ2 RASGRP3 Homo sapiens Q8IV61
Y2H Prey Pooling
25416956
Intra DYNLL2 Q96FJ2 PKIG Homo sapiens Q9Y2B9
Validated Y2H
32296183
Intra DYNLL2 Q96FJ2 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra DYNLL2 Q96FJ2 HMBOX1 Homo sapiens Q6NT76
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
Intra DYNLL2 Q96FJ2 HMBOX1 Homo sapiens Q6NT76
Y2H Array
25416956
Intra DYNLL2 Q96FJ2 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
25416956
Intra DYNLL2 Q96FJ2 KANK2 Homo sapiens Q63ZY3
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 KANK2 Homo sapiens Q63ZY3
Anti Tag CoIP
35271311
Intra DYNLL2 Q96FJ2 SECISBP2L Homo sapiens Q93073
Validated Y2H
25416956
Intra DYNLL2 Q96FJ2 SECISBP2L Homo sapiens Q93073
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 DYNC1I1 Homo sapiens O14576
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 FAM117B Homo sapiens Q6P1L5
Anti Tag CoIP
35271311
Intra DYNLL2 Q96FJ2 FAM117B Homo sapiens Q6P1L5
Y2H Prey Pooling
32296183
Intra DYNLL2 Q96FJ2 FAM117B Homo sapiens Q6P1L5
Y2H Array
32296183
Intra DYNLL2 Q96FJ2 FAM117B Homo sapiens Q6P1L5
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 FAM117B Homo sapiens Q6P1L5
TAP
27173435
Intra DYNLL2 Q96FJ2 BMF Homo sapiens Q96LC9
Y2H Prey Pooling
25416956
Intra DYNLL2 Q96FJ2 XIAP Homo sapiens P98170
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 XIAP Homo sapiens P98170
TAP
27173435
Intra DYNLL2 Q96FJ2 XIAP Homo sapiens P98170
Anti Tag CoIP
35271311
Intra DYNLL2 Q96FJ2 XIAP Homo sapiens P98170
Y2H Pooling
16189514
Intra DYNLL2 Q96FJ2 XIAP Homo sapiens P98170
Y2H Array
31515488
Intra DYNLL2 Q96FJ2 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra DYNLL2 Q96FJ2 TLK1 Homo sapiens Q9UKI8
Y2H Prey Pooling
32296183
Intra DYNLL2 Q96FJ2 TLK1 Homo sapiens Q9UKI8
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 TLK1 Homo sapiens Q9UKI8
Validated Y2H
32296183
Intra DYNLL2 Q96FJ2 TLK1 Homo sapiens Q9UKI8
Y2H Array
32296183
Intra DYNLL2 Q96FJ2 TLK1 Homo sapiens Q9UKI8
Anti Tag CoIP
35271311
Intra DYNLL2 Q96FJ2 DNAL4 Homo sapiens O96015
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 DNAL4 Homo sapiens O96015
Y2H Array
31515488
Intra DYNLL2 Q96FJ2 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra DYNLL2 Q96FJ2 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra DYNLL2 Q96FJ2 HOMER3 Homo sapiens Q9NSC5
Anti Tag CoIP
33961781
Intra DYNLL2 Q96FJ2 MORN3 Homo sapiens Q6PF18
Validated Y2H
25416956
Cross DYNLL2 Q96FJ2 rex_htlv2 Human T-cell leukemia virus Q85601
MAPPIT
22458338
Cross DYNLL2 Q96FJ2 rex_htl1c Human T-cell leukemia virus 1 P0C206
Y2H Pooling
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Short-Rib Thoracic Dysplasia 11 With Or Without Polydactyly

SRTD11
Bardet-Biedl Syndrome 7

BBS7

Bardet-Biedl Syndrome, Type 7
Louping Ill
Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy

Jeune Syndrome

Asphyxiating Thoracic Dysplasia

Short-Rib Thoracic Dysplasia With Or Without Polydactyly

Thoracic Pelvic Phalangeal Dystrophy

Asphyxiating Thoracic Chondrodystrophy

Atd

Chondroectodermal Dysplasia-Like Syndrome

Infantile Thoracic Dystrophy

Jeune Thoracic Dysplasia

Thoracic Asphyxiant Dystrophy

Thoracic-Pelvic-Phalangeal Dystrophy

Short-Rib Thoracic Dysplasia Without Polydactyly

Asphyxiating Thoracic Dystrophy Of The Newborn

Asphyxiating Thorax Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04089 DYNLL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DYNLL2 VGNC VGNC:98902
Mus musculus DYNLL2 MGD MGI:1915347
Rattus norvegicus DYNLL2 RGD RGD:619860
Canis familiaris DYNLL2 VGNC VGNC:40151
Bos taurus DYNLL2 VGNC VGNC:28275