CORO1A - coronin 1A Gene

Homo sapiens

Also known as p57; IMD8; TACO; CLABP; HCORO1; CLIPINA

Gene ID: 11151 | Gene type: protein coding

About CORO1A

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,183,602-30,189,076 (from NCBI)

This gene has 18 transcripts (splice variants), 186 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 216.7), bone marrow (RPKM 179.6) and 10 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

CORO1A Products(2)

mRNA	Protein	Name
NM_001193333.3	NP_001180262.1	coronin-1A
NM_007074.4	NP_009005.1	coronin-1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IPI IPI: Inferred from physical interaction	23100250	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	7758584	GOA
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	22364218	GOA
enables actin monomer binding	IMP IMP: Inferred from mutant phenotype	23100250	GOA
enables myosin heavy chain binding	IPI IPI: Inferred from physical interaction	23100250	GOA
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	11094157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9365277	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15601263	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17442961	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	17442961	GOA
NOT involved in immunological synapse formation	IMP IMP: Inferred from mutant phenotype	24760828	GOA
involved in natural killer cell degranulation	IMP IMP: Inferred from mutant phenotype	24760828	GOA
involved in negative regulation of actin nucleation	IDA IDA: Inferred from direct assay	17442961	GOA
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	17442961	GOA
involved in phagolysosome assembly	IMP IMP: Inferred from mutant phenotype	12132654	GOA
involved in positive chemotaxis	IDA IDA: Inferred from direct assay	17442961	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24760828	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IDA IDA: Inferred from direct assay	15800061	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	24760828	GOA
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	15800061	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17341475	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	24760828	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	17442961	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	17341475	GOA
located in phagocytic cup	IDA IDA: Inferred from direct assay	17442961	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	17442961	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17341475	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11094157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO1A Protein Structure

DUF1899

WD40

Trimer_CC

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

coronin-1A

clipin-A

CORO1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CORO1A	P31146	STAT3	Homo sapiens	P40763	Y2H	21988832
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	31515488
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	25416956
Intra	CORO1A	P31146	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	CORO1A	P31146	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Validated Y2H	32296183
Intra	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183
Intra	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Validated Y2H	32296183
Intra	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 8

Severe Combined Immunodeficiency Due To Coro1a Deficiency	IMD8
Scid Due To Coro1a Deficiency	Scid Due To Coronin-1a Deficiency
Severe Combined Immunodeficiency Due To Coronin-1a Deficiency	Immunodeficiency, Type 8

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Coronin-1a Deficiency

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Immunodeficiency 19

IMD19	Cd3-Delta Deficiency
Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Cd3delta Deficiency
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Immunodeficiency 19, Severe Combined
Cd3d	Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive
T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid	T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency
Immunodeficiency, Type 19

Immunodeficiency 40

Dock2 Deficiency	IMD40
Immunodeficiency, Type 40

Lymphopenia

Lymphocytopenia

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Immunodeficiency 7

Tcr-Alpha-Beta-Positive T-Cell Deficiency	IMD7
T-Cell Receptor-Alpha/Beta Deficiency	Immunodeficiency 7, Tcr-Alpha/Beta Deficient
Tcr-Alpha/Beta Deficiency	Tcr-Alpha-Beta+ T-Cell Deficiency
T-Cell Receptor Alpha/Beta Deficiency

Immunodeficiency 9

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 1	Combined Immunodeficiency Due To Orai1 Deficiency
IMD9	Cid Due To Orai1 Deficiency
Severe Combined Immunodeficiency Due To Crac Channel Dysfunction	Immunodeficiency, Type 9

Immunodeficiency 20

Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Natural Killer Cell Cytotoxicity	IMD20
Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Nk Cell Cytotoxicity	Cd16 Deficiency
Immunodeficiency, Type 20

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

XMEN	X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
Cid Due To Magt1 Deficiency	Combined Immunodeficiency Due To Magt1 Deficiency
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An	X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia

Lymphoproliferative Syndrome 2

Cd27 Deficiency	LPFS2
Combined Immunodeficiency Due To Cd27 Deficiency	Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

T Cell Deficiency

T Cell Immunodeficiency	T Lymphocyte Deficiency
T Lymphocyte Immunodeficiency	T-Lymphocyte Deficiency

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03048	CORO1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CORO1A	VGNC	VGNC:61101
Mus musculus	CORO1A	MGD	MGI:1345961
Macaca mulatta	CORO1A	VGNC	VGNC:71319
Bos taurus	CORO1A	VGNC	VGNC:27620
Canis familiaris	CORO1A	VGNC	VGNC:39527
Rattus norvegicus	CORO1A	RGD	RGD:620009

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