FSD2 - fibronectin type III and SPRY domain containing 2 Gene

Homo sapiens

Also known as SPRYD1

Gene ID: 123722 | Gene type: protein coding

About FSD2

This gene has 3 transcripts (splice variants), 194 orthologues and 3 paralogues. Biased expression in heart (RPKM 7.7), prostate (RPKM 0.9) and 6 other tissues.

Summary

This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FSD2 Products(3)

mRNA	Protein	Name
NM_001007122.4	NP_001007123.1	fibronectin type III and SPRY domain-containing protein 2 isoform a
NM_001281805.2	NP_001268734.1	fibronectin type III and SPRY domain-containing protein 2 isoform b
NM_001281806.2	NP_001268735.1	fibronectin type III and SPRY domain-containing protein 2 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FSD2 Protein Structure

fn3

SPRY

0
200
400
600
749 a.a.

Protein Preferred Names

Protein Names

fibronectin type III and SPRY domain-containing protein 2

SPRY domain containing 1

FSD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FSD2	A1L4K1	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	32296183
Intra	FSD2	A1L4K1	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF572	Homo sapiens	Q7Z3I7	MAPPIT	25416956
Intra	FSD2	A1L4K1	ZNF572	Homo sapiens	Q7Z3I7	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	ZNF572	Homo sapiens	Q7Z3I7	Validated Y2H	25416956
Intra	FSD2	A1L4K1	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	FSD2	A1L4K1	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	FSD2	A1L4K1	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	FSD2	A1L4K1	FAM107A	Homo sapiens	O95990-3	Y2H Array	25416956
Intra	FSD2	A1L4K1	FMR1	Homo sapiens	Q06787-8	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	FMR1	Homo sapiens	Q06787-8	Validated Y2H	25416956
Intra	FSD2	A1L4K1	FMR1	Homo sapiens	Q06787-8	Y2H Array	25416956
Intra	FSD2	A1L4K1	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	FSD2	A1L4K1	PBX3	Homo sapiens	Q5JS98	Y2H Array	25416956
Intra	FSD2	A1L4K1	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	32296183
Intra	FSD2	A1L4K1	LATS1	Homo sapiens	Q6PJG3	Validated Y2H	25416956
Intra	FSD2	A1L4K1	LATS1	Homo sapiens	Q6PJG3	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	BRD8	Homo sapiens	Q9H0E9-2	Validated Y2H	25416956
Intra	FSD2	A1L4K1	BRD8	Homo sapiens	Q9H0E9-2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	BRD8	Homo sapiens	Q9H0E9-2	Y2H Array	25416956
Intra	FSD2	A1L4K1	SH2D4A	Homo sapiens	Q9H788-2	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	POLL	Homo sapiens	Q9UGP5-2	Y2H Array	25416956
Intra	FSD2	A1L4K1	POLL	Homo sapiens	Q9UGP5-2	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	CORO1A	Homo sapiens	P31146	Validated Y2H	25416956
Intra	FSD2	A1L4K1	CORO1A	Homo sapiens	P31146	Validated Y2H	32296183
Intra	FSD2	A1L4K1	EXOC3	Homo sapiens	O60645	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ESD	Homo sapiens	P10768	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ESD	Homo sapiens	P10768	Anti Tag CoIP	33961781
Intra	FSD2	A1L4K1	ESD	Homo sapiens	P10768	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF35	Homo sapiens	P13682	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF230	Homo sapiens	Q9UIE0	Y2H Array	25416956
Intra	FSD2	A1L4K1	ZNF230	Homo sapiens	Q9UIE0	Validated Y2H	25416956
Intra	FSD2	A1L4K1	ZNF230	Homo sapiens	Q9UIE0	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	ZNF490	Homo sapiens	Q9ULM2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	FSD2	A1L4K1	CTAG1A	Homo sapiens	P78358	Validated Y2H	32296183
Intra	FSD2	A1L4K1	HDAC4	Homo sapiens	P56524-2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF777	Homo sapiens	Q9ULD5	Validated Y2H	32296183
Intra	FSD2	A1L4K1	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	FSD2	A1L4K1	DTNB	Homo sapiens	O60941-5	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF648	Homo sapiens	Q5T619	Validated Y2H	32296183
Intra	FSD2	A1L4K1	SPATC1L	Homo sapiens	Q9H0A9-2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	FSD2	A1L4K1	DCX	Homo sapiens	O43602-2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	32296183
Intra	FSD2	A1L4K1	UBTFL1	Homo sapiens	P0CB47	Validated Y2H	32296183
Intra	FSD2	A1L4K1	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	FSD2	A1L4K1	CAMSAP3	Homo sapiens	Q9P1Y5-2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	FARS2	Homo sapiens	O95363	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF124	Homo sapiens	Q15973	Y2H Array	25416956
Intra	FSD2	A1L4K1	ZNF124	Homo sapiens	Q15973	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	ZNF124	Homo sapiens	Q15973	Validated Y2H	25416956
Intra	FSD2	A1L4K1	PPP1R18	Homo sapiens	Q6NYC8	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	25416956
Intra	FSD2	A1L4K1	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	25416956
Intra	FSD2	A1L4K1	ATG14	Homo sapiens	Q6ZNE5	Validated Y2H	32296183
Intra	FSD2	A1L4K1	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	FSD2	A1L4K1	OXNAD1	Homo sapiens	Q96HP4	Validated Y2H	32296183
Intra	FSD2	A1L4K1	SNAPIN	Homo sapiens	O95295	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
Intra	FSD2	A1L4K1	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	FSD2	A1L4K1	SPATC1L	Homo sapiens	Q9H0A9	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	SPATC1L	Homo sapiens	Q9H0A9	Y2H Array	25416956
Intra	FSD2	A1L4K1	RNF8	Homo sapiens	O76064	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZSCAN26	Homo sapiens	Q16670	Y2H Array	25416956
Intra	FSD2	A1L4K1	ZSCAN26	Homo sapiens	Q16670	Validated Y2H	25416956
Intra	FSD2	A1L4K1	PPP2R5D	Homo sapiens	Q14738	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	32296183
Intra	FSD2	A1L4K1	OIP5	Homo sapiens	O43482	Validated Y2H	32296183
Intra	FSD2	A1L4K1	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	32296183
Intra	FSD2	A1L4K1	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	FSD2	A1L4K1	PSMB4	Homo sapiens	P28070	Validated Y2H	25416956
Intra	FSD2	A1L4K1	PSMB4	Homo sapiens	P28070	Y2H Array	25416956
Intra	FSD2	A1L4K1	PSMB4	Homo sapiens	P28070	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	ARFIP2	Homo sapiens	P53365	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF587	Homo sapiens	Q96SQ5	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF587	Homo sapiens	Q96SQ5	Y2H Array	25416956
Intra	FSD2	A1L4K1	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	FSD2	A1L4K1	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
Intra	FSD2	A1L4K1	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	CBX8	Homo sapiens	Q9HC52	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	FSD2	A1L4K1	CBX8	Homo sapiens	Q9HC52	Y2H Array	25416956
Intra	FSD2	A1L4K1	ZNF20	Homo sapiens	P17024	Y2H Array	25416956
Intra	FSD2	A1L4K1	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	FSD2	A1L4K1	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	FSD2	A1L4K1	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	FSD2	A1L4K1	ZNF410	Homo sapiens	Q86VK4	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	ZNF76	Homo sapiens	P36508	Validated Y2H	32296183
Intra	FSD2	A1L4K1	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	32296183
Intra	FSD2	A1L4K1	LENG1	Homo sapiens	Q96BZ8	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	FSD2	A1L4K1	HGS	Homo sapiens	O14964	Validated Y2H	32296183
Intra	FSD2	A1L4K1	KANSL1	Homo sapiens	Q7Z3B3	Y2H Array	25416956
Intra	FSD2	A1L4K1	KANSL1	Homo sapiens	Q7Z3B3	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	KANSL1	Homo sapiens	Q7Z3B3	Validated Y2H	25416956
Intra	FSD2	A1L4K1	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
Intra	FSD2	A1L4K1	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	FSD2	A1L4K1	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	FSD2	A1L4K1	THAP7	Homo sapiens	Q9BT49	Validated Y2H	32296183
Intra	FSD2	A1L4K1	BEX3	Homo sapiens	Q00994	Validated Y2H	32296183
Intra	FSD2	A1L4K1	BEX3	Homo sapiens	Q00994	Y2H Array	25416956
Intra	FSD2	A1L4K1	BEX3	Homo sapiens	Q00994	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	FAM50B	Homo sapiens	Q9Y247	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	FSD2	A1L4K1	IFT20	Homo sapiens	Q8IY31	Validated Y2H	25416956
Intra	FSD2	A1L4K1	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	FSD2	A1L4K1	CCDC112	Homo sapiens	Q8NEF3	Validated Y2H	25416956
Intra	FSD2	A1L4K1	CCDC112	Homo sapiens	Q8NEF3	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	AQP1	Homo sapiens	P29972	Y2H Array	25416956
Intra	FSD2	A1L4K1	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
Intra	FSD2	A1L4K1	CDK18	Homo sapiens	Q07002	Validated Y2H	32296183
Intra	FSD2	A1L4K1	ZNF580	Homo sapiens	Q9UK33	Validated Y2H	32296183
Intra	FSD2	A1L4K1	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	25416956
Intra	FSD2	A1L4K1	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
Intra	FSD2	A1L4K1	SH2D4A	Homo sapiens	Q9H788	Y2H Array	25416956
Intra	FSD2	A1L4K1	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	FSD2	A1L4K1	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	FSD2	A1L4K1	PIK3R3	Homo sapiens	Q8N381	Y2H Prey Pooling	25416956
Intra	FSD2	A1L4K1	PIK3R3	Homo sapiens	Q8N381	Y2H Array	25416956
Intra	FSD2	A1L4K1	KLHL40	Homo sapiens	Q2TBA0	Validated Y2H	32296183
Intra	FSD2	A1L4K1	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
Intra	FSD2	A1L4K1	CDC73	Homo sapiens	Q6P1J9	Y2H Array	31515488
Intra	FSD2	A1L4K1	TCEANC	Homo sapiens	Q8N8B7	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05122	FSD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FSD2	VGNC	VGNC:40995
Felis catus	FSD2	VGNC	VGNC:62377
Macaca mulatta	FSD2	VGNC	VGNC:72738
Bos taurus	FSD2	VGNC	VGNC:29131
Rattus norvegicus	FSD2	RGD	RGD:1305167
Mus musculus	FSD2	MGD	MGI:2444310

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