2. Gene
  3. FICD - FIC domain protein adenylyltransferase Gene

FICD - FIC domain protein adenylyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HYPE; HIP13; UNQ3041

Gene ID: 11153 | Gene type: protein coding

About FICD

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in thyroid (RPKM 7.5), testis (RPKM 4.5) and 25 other tissues.

Summary

Enables several functions, including ATP binding activity; HSP70 protein binding activity; and chaperone binding activity. Involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

FICD Products(1)

mRNA Protein Name
NM_007076.3 NP_009007.2 protein adenylyltransferase FICD
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables AMPylase activity IDA
IDA: Inferred from direct assay
19362538 GOA
enables ATP binding IDA
IDA: Inferred from direct assay
25435325 GOA
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
25601083 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22266942 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
25435325 GOA
enables protein-folding chaperone binding IDA
IDA: Inferred from direct assay
25601083 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein adenylylation IDA
IDA: Inferred from direct assay
22266942 GOA
involved in regulation of IRE1-mediated unfolded protein response IDA
IDA: Inferred from direct assay
25601083 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
25601083 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25601083 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FICD Protein Structure

Fic

Fic: Fic/DOC family (285 - 381)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

protein adenylyltransferase FICD

AMPylator FICD

FICD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra FICD Q9BVA6 FICD Homo sapiens Q9BVA6
X-Ray Diffraction
25435325
Intra FICD Q9BVA6 ADK Homo sapiens P55263
Y2H Array
21988832
Intra FICD Q9BVA6 RAC1 Homo sapiens P63000-1
Ampylation
22266942
Intra FICD Q9BVA6 FICD Homo sapiens Q9BVA6
GMS
25435325
Intra FICD Q9BVA6 CDC42 Homo sapiens P60953-2
Ampylation
22266942
Intra FICD Q9BVA6 FICD Homo sapiens Q9BVA6
SAXS
25435325
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cone-Rod Dystrophy 13

CORD13

Dystrophy, Cone-Rod, Type 13
Alcoholic Psychosis

Psychoses, Alcoholic

Alcoholic Psychoses
Progressive Familial Heart Block

Hereditary Bundle Branch Defect

Hereditary Bundle Branch System Defect

Familial Lenegre Disease

Familial Lev Disease

Familial Lev-Lenegre Disease

Familial Pccd

Familial Progressive Heart Block

Pfhb

Bundle Branch Block

Hbbd

Lenegre Lev Disease

Lev Syndrome

Lev'S Disease

Lev-Lenègre Disease

Pccd

Progressive Cardiac Conduction Defect

Bundle-Branch Block
Schizotypal Personality Disorder

Schizotypal Personality
Cholestasis, Progressive Familial Intrahepatic, 1

PFIC1

Byler Disease

Cholestasis, Progressive Familial Intrahepatic 1

Progressive Familial Intrahepatic Cholestasis 1

Progressive Familial Intrahepatic Cholestasis Type 1

Fic1 Deficiency

Byler'S Disease

Cholestasis, Fatal Intrahepatic

Progressive Familial Intrahepatic Cholestasis

Severe Atp8b1 Deficiency

Fatal Intrahepatic Cholestasis

Cholestasis, Intrahepatic, Familial, Progressive, Type 1

Progressive Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic 3
Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma

Adult Hepatoma

Adult Hcc
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04943 FICD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FICD VGNC VGNC:107705
Rattus norvegicus FICD RGD RGD:1359391
Bos taurus FICD VGNC VGNC:29007
Mus musculus FICD MGD MGI:1098550
Macaca mulatta FICD VGNC VGNC:82081
Canis familiaris FICD VGNC VGNC:52933