NUDT3 - nudix hydrolase 3 Gene

Homo sapiens

Also known as DIPP; DIPP1; DIPP-1

Gene ID: 11165 | Gene type: protein coding

About NUDT3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,279,679-34,392,669 (from NCBI)

This gene has 1 transcript (splice variant), 227 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 33.6), thyroid (RPKM 19.6) and 25 other tissues.

Summary

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

NUDT3 Products(1)

mRNA	Protein	Name
NM_006703.4	NP_006694.1	diphosphoinositol polyphosphate phosphohydrolase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	IDA IDA: Inferred from direct assay	32727897	GOA
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IDA IDA: Inferred from direct assay	32727897	GOA
enables diphosphoinositol-polyphosphate diphosphatase activity	IDA IDA: Inferred from direct assay	9822604	GOA
enables endopolyphosphatase activity	IDA IDA: Inferred from direct assay	34788624	GOA
enables inositol diphosphate pentakisphosphate diphosphatase activity	IDA IDA: Inferred from direct assay	9822604	GOA
enables inositol diphosphate pentakisphosphate diphosphatase activity	IMP IMP: Inferred from mutant phenotype	10585413	GOA
enables inositol diphosphate tetrakisphosphate diphosphatase activity	IDA IDA: Inferred from direct assay	9822604	GOA
enables inositol diphosphate tetrakisphosphate diphosphatase activity	IMP IMP: Inferred from mutant phenotype	10585413	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	19585659	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	34788624	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	34788624	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA decapping	IDA IDA: Inferred from direct assay	32727897	GOA
involved in RNA decapping	IMP IMP: Inferred from mutant phenotype	26932476	GOA
involved in diadenosine hexaphosphate catabolic process	IDA IDA: Inferred from direct assay	34788624	GOA
involved in diphosphoinositol polyphosphate catabolic process	IDA IDA: Inferred from direct assay	10585413	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	34788624	GOA
located in nucleus	IDA IDA: Inferred from direct assay	34788624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT3 Protein Structure

NUDIX

0
100
172 a.a.

Protein Preferred Names

Protein Names

diphosphoinositol polyphosphate phosphohydrolase 1

diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09671	NUDT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUDT3	RGD	RGD:1310183
Bos taurus	NUDT3	VGNC	VGNC:32338
Mus musculus	NUDT3	MGD	MGI:1928484
Macaca mulatta	NUDT3	VGNC	VGNC:75551
Canis familiaris	NUDT3	VGNC	VGNC:57226

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