WBP4 - WW domain binding protein 4 Gene

Homo sapiens

Also known as FBP21

Gene ID: 11193 | Gene type: protein coding

About WBP4

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:41,061,509-41,084,006 (from NCBI)

This gene has 1 transcript (splice variant) and 204 orthologues. Ubiquitous expression in brain (RPKM 9.7), fat (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

WBP4 Products(1)

mRNA	Protein	Name
NM_007187.5	NP_009118.1	WW domain-binding protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables proline-rich region binding	IPI IPI: Inferred from physical interaction	19592703	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA cis splicing, via spliceosome	IDA IDA: Inferred from direct assay	19592703	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	19592703	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28781166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WBP4 Protein Structure

zf-U1

0
100
200
300
376 a.a.

Protein Preferred Names

Protein Names

WW domain-binding protein 4

WBP-4

WBP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WBP4	O75554	RBM45	Homo sapiens	Q8IUH3	Anti Tag CoIP	33961781
Intra	WBP4	O75554	HTT	Homo sapiens	P42858	Y2H	17500595

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15752	WBP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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