2. Gene
  3. RBM45 - RNA binding motif protein 45 Gene

RBM45 - RNA binding motif protein 45 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DRB1; RB-1

Gene ID: 129831 | Gene type: protein coding

About RBM45

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,112,437-178,139,011 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 3.5), lymph node (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

RBM45 Products(3)

mRNA Protein Name
NM_001365578.1 NP_001352507.1 RNA-binding protein 45 isoform 1
NM_001365579.1 NP_001352508.1 RNA-binding protein 45 isoform 2
NM_152945.4 NP_694453.2 RNA-binding protein 45 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
12220514 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12220514 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12220514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM45 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (34 - 92)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (127 - 183)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (409 - 458)

  • 0
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  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 45

developmentally regulated RNA-binding protein 1

RBM45 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RBM45 Q8IUH3 MEMO1 Homo sapiens Q9Y316
Y2H Array
25416956
Intra
RBM45 Q8IUH3 MEMO1 Homo sapiens Q9Y316
Y2H Prey Pooling
25416956
Intra
RBM45 Q8IUH3 FANCL Homo sapiens Q9NW38
Y2H Prey Pooling
25416956
Intra
RBM45 Q8IUH3 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
Intra
RBM45 Q8IUH3 MATR3 Homo sapiens P43243
IF
26979993
Intra
RBM45 Q8IUH3 MATR3 Homo sapiens P43243
Anti Tag CoIP
26979993
Intra
RBM45 Q8IUH3 MATR3 Homo sapiens P43243
Crosslink
26979993
Intra
RBM45 Q8IUH3 HNRNPA1 Homo sapiens P09651
Anti Tag CoIP
26979993
Intra
RBM45 Q8IUH3 HNRNPA1 Homo sapiens P09651
Crosslink
26979993
Intra
RBM45 Q8IUH3 HNRNPA1 Homo sapiens P09651
IF
26979993
Intra
RBM45 Q8IUH3 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra
RBM45 Q8IUH3 HNRNPL Homo sapiens P14866
Crosslink
26979993
Intra
RBM45 Q8IUH3 HNRNPL Homo sapiens P14866
Anti Tag CoIP
26979993
Intra
RBM45 Q8IUH3 HNRNPL Homo sapiens P14866
IF
26979993
Intra
RBM45 Q8IUH3 RBM14 Homo sapiens Q96PK6
Anti Tag CoIP
26979993
Intra
RBM45 Q8IUH3 RBM14 Homo sapiens Q96PK6
Crosslink
26979993
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Tick Infestation

Tick Infestations
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122054A BPK-29 hydrochloride Inhibitor 98.28% Unkown
HY-122054 BPK-29 Inhibitor 99.4% Unkown
HY-RS11754 RBM45 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RBM45 VGNC VGNC:52814
Felis catus RBM45 VGNC VGNC:64533
Mus musculus RBM45 MGD MGI:2387367
Canis familiaris RBM45 VGNC VGNC:53104
Macaca mulatta RBM45 VGNC VGNC:76527
Rattus norvegicus RBM45 RGD RGD:628862