FZD10 - frizzled class receptor 10 Gene

Homo sapiens

Also known as Fz10; FzE7; CD350; FZ-10; hFz10

Gene ID: 11211 | Gene type: protein coding

About FZD10

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,162,464-130,165,740 (from NCBI)

This gene has 2 transcripts (splice variants), 190 orthologues and 15 paralogues.

Summary

This gene is a member of the Frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon Cancer. [provided by RefSeq, Jul 2008]

FZD10 Products(1)

mRNA	Protein	Name
NM_007197.4	NP_009128.1	frizzled-10 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	28733458	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15930302	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	28733458	GOA
involved in non-canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19137009	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	19137009	GOA
acts upstream of regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	19137009	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	18271942	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16007199	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD10 Protein Structure

Frizzled

0
100
200
300
400
500
581 a.a.

Protein Preferred Names

Protein Names

frizzled-10

frizzled 10, seven transmembrane spanning receptor

FZD10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FZD10	Q9ULW2	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	FZD10	Q9ULW2	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	FZD10	Q9ULW2	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	FZD10	Q9ULW2	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	FZD10	Q9ULW2	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	FZD10	Q9ULW2	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	FZD10	Q9ULW2	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	FZD10	Q9ULW2	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	FZD10	Q9ULW2	P4HB	Homo sapiens	P07237	Y2H Prey Pooling	32296183
Intra	FZD10	Q9ULW2	P4HB	Homo sapiens	P07237	Y2H Array	32296183
Intra	FZD10	Q9ULW2	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183
Intra	FZD10	Q9ULW2	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183
Intra	FZD10	Q9ULW2	HILPDA	Homo sapiens	Q9Y5L2	Anti Bait CoIP	15930302

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74146	Frizzled-10/CD350 Protein, Human (HEK293, His)	NP_009128.1 (I21-G161)	≥95%
HY-P74147	Frizzled-10/CD350 Protein, Human (HEK293, Fc)	NP_009128.1 (I21-G161)	≥95%

Related Diseases

Diseases

Alias

Fallopian Tube Serous Adenocarcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05177	FZD10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99581	Tabituximab barzuxetan (exclude Y90)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FZD10	RGD	RGD:1583825
Canis familiaris	FZD10	VGNC	VGNC:41029
Felis catus	FZD10	VGNC	VGNC:62403
Mus musculus	FZD10	MGD	MGI:2136761
Macaca mulatta	FZD10	VGNC	VGNC:72833
Bos taurus	FZD10	VGNC	VGNC:29166
Others	FZD10	NCBI

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