HILPDA - hypoxia inducible lipid droplet associated Gene

Homo sapiens

Also known as HIG2; HIG-2; C7orf68

Gene ID: 29923 | Gene type: protein coding

About HILPDA

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,455,878-128,458,418 (from NCBI)

This gene has 4 transcripts (splice variants) and 43 orthologues. Broad expression in esophagus (RPKM 37.4), fat (RPKM 20.9) and 20 other tissues.

Summary

Enables signaling receptor binding activity. Involved in several processes, including autocrine signaling; cellular response to hypoxia; and positive regulation of lipid storage. Located in several cellular components, including cell surface; lipid droplet; and secretory granule. [provided by Alliance of Genome Resources, Apr 2022]

HILPDA Products(2)

mRNA	Protein	Name
NM_001098786.2	NP_001092256.1	hypoxia-inducible lipid droplet-associated protein
NM_013332.4	NP_037464.1	hypoxia-inducible lipid droplet-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15930302	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	15930302	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autocrine signaling	IDA IDA: Inferred from direct assay	15930302	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	10690527	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15930302	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	20624928	GOA
involved in positive regulation of lipid storage	IDA IDA: Inferred from direct assay	20624928	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15930302	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	15930302	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	20624928	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	15930302	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HILPDA Protein Structure

HILPDA

0
63 a.a.

Protein Preferred Names

Protein Names

hypoxia-inducible lipid droplet-associated protein

hypoxia inducible gene 2

HILPDA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HILPDA	Q9Y5L2	GET3	Homo sapiens	O43681	Validated Y2H	25416956
Intra	HILPDA	Q9Y5L2	GET3	Homo sapiens	O43681	Y2H Array	25416956
Intra	HILPDA	Q9Y5L2	GET3	Homo sapiens	O43681	Y2H Prey Pooling	25416956
Intra	HILPDA	Q9Y5L2	FZD10	Homo sapiens	Q9ULW2	Anti Bait CoIP	15930302

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06174	HILPDA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HILPDA	VGNC	VGNC:73451
Rattus norvegicus	HILPDA	RGD	RGD:2319900
Mus musculus	HILPDA	MGD	MGI:1916823

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