IRAK3 - interleukin 1 receptor associated kinase 3 Gene

Homo sapiens

Also known as ASRT5; IRAKM

Gene ID: 11213 | Gene type: protein coding

About IRAK3

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:66,189,214-66,254,622 (from NCBI)

This gene has 3 transcripts (splice variants), 154 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 10.8), spleen (RPKM 8.1) and 21 other tissues.

Summary

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like Receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

IRAK3 Products(2)

mRNA	Protein	Name
NM_001142523.2	NP_001135995.1	interleukin-1 receptor-associated kinase 3 isoform b
NM_007199.3	NP_009130.2	interleukin-1 receptor-associated kinase 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10383454	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10383454	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29686383	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10383454	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	33238146	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10383454	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	33238146	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10383454	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17379480	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in negative regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	18156187	GOA
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18156187	GOA
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	17379480	GOA
involved in negative regulation of protein-containing complex disassembly	IMP IMP: Inferred from mutant phenotype	12150927	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15728517	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10383454	GOA
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	10383454	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17379480	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17379480	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRAK3 Protein Structure

Death

Pkinase

0
100
200
300
400
500
596 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor-associated kinase 3

IL-1 receptor-associated kinase M

Related Diseases

Diseases

Alias

Asthma-Related Traits 5

Asthma-Related Traits, Susceptibility To, 5	ASRT5
Asthma Susceptibility 5	Asthma-Related Traits, Susceptibility To, Type 5

Multisystem Inflammatory Syndrome In Children

Mis-C	Multisystem Inflammatory Disorder In Children And Adolescents
Paediatric Inflammatory Multisystemic Syndrome	Mic

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Lung Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Lung

Deafness, Autosomal Recessive 74

DFNB74	Autosomal Recessive Nonsyndromic Deafness 74
Autosomal Recessive Deafness 74	Deafness, Autosomal Recessive, 74
Deafness, Autosomal Recessive, Type 74

Pleuropneumonia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142662A	PROTAC IRAK3 degrade-1 formic		98.10%	Unkown
HY-142662	PROTAC IRAK3 degrade-1	Modulator	/	Unkown
HY-RS06897	IRAK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRAK3	MGD	MGI:1921164
Bos taurus	IRAK3	VGNC	VGNC:30267
Rattus norvegicus	IRAK3	RGD	RGD:1308846
Felis catus	IRAK3	VGNC	VGNC:62971
Macaca mulatta	IRAK3	VGNC	VGNC:81423
Canis familiaris	IRAK3	VGNC	VGNC:54151
Others	IRAK3	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.