PROTAC IRAK3 degrade-1 formic

Name: PROTAC IRAK3 degrade-1 formic
Brand: MedChemExpress
SKU: HY-142662A
Rating: 4.5 (1 reviews)

Cat. No.: HY-142662A Purity: 98.10%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PROTAC IRAK3 degrade-1 (compound 23) formic is a potent and selective degrader of IRAK3 (IC₅₀=5 nM).

For research use only. We do not sell to patients.

PROTAC IRAK3 degrade-1 formic Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1580	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3320	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 5320	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 8500	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PROTAC IRAK3 degrade-1 formic:

PROTAC IRAK3 degrade-1 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC IRAK3 degrade-1 (compound 23) formic is a potent and selective degrader of IRAK3 (IC₅₀=5 nM)^[1].

IC₅₀ & Target

IRAK3^[1]

Molecular Weight

924.10

Formula

C₄₈H₆₅N₁₁O₈

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(N3CCN(CC3)CCC4CCN(CC4)C(CCC(N5CCN([C@@]6([H])CC[C@H](CC6)NC7=NC=NN8C7=C(C(C)C)C=C8)CC5)=O)=O)=CC=C2C(N1C9C(NC(CC9)=O)=O)=O.O=CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 150 mg/mL (162.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0821 mL	5.4107 mL	10.8213 mL
5 mM	0.2164 mL	1.0821 mL	2.1643 mL
10 mM	0.1082 mL	0.5411 mL	1.0821 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 5% DMSO 40% PEG300 5% Tween-80 50% Saline
Solubility: ≥ 1.25 mg/mL (1.35 mM); Clear solution
Protocol 2

Add each solvent one by one: 5% DMSO 95% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (1.35 mM); Clear solution

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 5 mg/mL (5.41 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.10%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (245 KB) HNMR (391 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Degorce SL, et al. Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase. J Med Chem. 2020 Sep 24;63(18):10460-10473. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0821 mL	5.4107 mL	10.8213 mL	27.0533 mL
	5 mM	0.2164 mL	1.0821 mL	2.1643 mL	5.4107 mL
	10 mM	0.1082 mL	0.5411 mL	1.0821 mL	2.7053 mL
	15 mM	0.0721 mL	0.3607 mL	0.7214 mL	1.8036 mL
	20 mM	0.0541 mL	0.2705 mL	0.5411 mL	1.3527 mL
	25 mM	0.0433 mL	0.2164 mL	0.4329 mL	1.0821 mL
	30 mM	0.0361 mL	0.1804 mL	0.3607 mL	0.9018 mL
	40 mM	0.0271 mL	0.1353 mL	0.2705 mL	0.6763 mL
	50 mM	0.0216 mL	0.1082 mL	0.2164 mL	0.5411 mL
	60 mM	0.0180 mL	0.0902 mL	0.1804 mL	0.4509 mL
	80 mM	0.0135 mL	0.0676 mL	0.1353 mL	0.3382 mL
	100 mM	0.0108 mL	0.0541 mL	0.1082 mL	0.2705 mL