RASSF8 - Ras association domain family member 8 Gene

Homo sapiens

Also known as HOJ1; C12orf2

Gene ID: 11228 | Gene type: protein coding

About RASSF8

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:25,958,232-26,079,889 (from NCBI)

This gene has 18 transcripts (splice variants), 283 orthologues and 3 paralogues. Broad expression in testis (RPKM 13.9), endometrium (RPKM 13.0) and 23 other tissues.

Summary

This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

RASSF8 Products(13)

mRNA	Protein	Name
NM_001164746.2	NP_001158218.1	ras association domain-containing protein 8 isoform a
NM_001164747.2	NP_001158219.1	ras association domain-containing protein 8 isoform a
NM_001164748.2	NP_001158220.1	ras association domain-containing protein 8 isoform a
NM_001394094.1	NP_001381023.1	ras association domain-containing protein 8 isoform a
NM_001394095.1	NP_001381024.1	ras association domain-containing protein 8 isoform a
NM_001394096.1	NP_001381025.1	ras association domain-containing protein 8 isoform a
NM_001394097.1	NP_001381026.1	ras association domain-containing protein 8 isoform a
NM_001394098.1	NP_001381027.1	ras association domain-containing protein 8 isoform a
NM_001394099.1	NP_001381028.1	ras association domain-containing protein 8 isoform a
NM_001394100.1	NP_001381029.1	ras association domain-containing protein 8 isoform a
NM_001394101.1	NP_001381030.1	ras association domain-containing protein 8 isoform a
NM_001394102.1	NP_001381031.1	ras association domain-containing protein 8 isoform a
NM_007211.5	NP_009142.2	ras association domain-containing protein 8 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASSF8 Protein Structure

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

ras association domain-containing protein 8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

RASSF8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RASSF8	Q8NHQ8	FRMD6	Homo sapiens	Q96NE9	Y2H Pooling	16189514
Intra	RASSF8	Q8NHQ8	FRMD6	Homo sapiens	Q96NE9	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Synpolydactyly

Syndactyly Type 2	Syndactyly, Type 2
Spd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11708	RASSF8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RASSF8	VGNC	VGNC:64511
Mus musculus	RASSF8	MGD	MGI:1918573
Rattus norvegicus	RASSF8	RGD	RGD:1308820
Bos taurus	RASSF8	VGNC	VGNC:33764
Macaca mulatta	RASSF8	VGNC	VGNC:76473
Canis familiaris	RASSF8	VGNC	VGNC:45385

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