PRR4 - proline rich 4 Gene

Homo sapiens

Also known as LPRP; PROL4

Gene ID: 11272 | Gene type: protein coding

About PRR4

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,845,849-10,849,475 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 14 orthologues and 6 paralogues. Restricted expression toward salivary gland (RPKM 1815.0).

Summary

This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]

PRR4 Products(2)

mRNA	Protein	Name
NM_001098538.3	NP_001092008.2	proline-rich protein 4 isoform 1 precursor
NM_007244.3	NP_009175.2	proline-rich protein 4 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR4 Protein Structure

Pro-rich

0
100
134 a.a.

Protein Preferred Names

Protein Names

proline-rich protein 4

lacrimal proline-rich protein

PRR4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRR4	Q16378	MIEF1	Homo sapiens	Q9NQG6	Validated Y2H	32296183
Intra	PRR4	Q16378	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	PRR4	Q16378	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	PRR4	Q16378	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PRR4	Q16378	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PRR4	Q16378	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ectodermal Dysplasia-Syndactyly Syndrome 1

EDSS1	Ectodermal Dysplasia-Syndactyly Syndrome
Edss	Dysplasia, Ectodermal, Syndactyly Syndrome, Type 1

Epicondylitis

Tennis Elbow	Lateral Epicondylitis
Golfer'S Elbow	Medial Epicondylitis
Andrel Epicondylitis	Archer'S Elbow
Hockey Elbow	Shooter'S Elbow

Rubeosis Iridis

Perforated Corneal Ulcer

Antisocial Personality Disorder

Dissocial Personality Disorder	Asocial Personality
Psychopath.Personality	Psychopathic Personality
Psychopathic Personality Disorder	Sociopathic Personality

Chronic Follicular Conjunctivitis

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Peroneal Nerve Paralysis

Peroneal Nerve Palsy

Papillary Conjunctivitis

Gingival Recession

Localized Gingival Recession	Gingival Recession, Localized
Minimal Gingival Recession	Moderate Gingival Recession
Severe Gingival Recession	Gingival Recession, Minimal
Gingival Recession, Severe	Atrophy Of Gums
Gum Atrophy	Gingival Atrophy

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Giant Papillary Conjunctivitis

Gpc	Conjunctivitis Giant Papillary
Conjunctivitis, Giant Papillary	Chronic Giant Papillary Conjunctivitis
Chronic Papillary Conjunctivitis

Dry Eye Syndrome

Dry Eye Syndromes	Dry Eye Disease
Tear Film Insufficiency	Xerophthalmia

White Sponge Nevus 1

White Sponge Nevus Of Cannon	Leukokeratosis, Hereditary Mucosal
Hereditary Mucosal Leukokeratosis	White Sponge Nevus
WSN1	Wsn
Cannon'S Disease	Familial White Folded Mucosal Dysplasia
Hereditary Leukokeratosis	Hereditary Oral Keratosis
Leukokeratosis Of Oral Mucosa	Nevus Of Cannon
White Folded Gingivostomatosis	White Gingivostomatitis
White Sponge Naevus	White Sponge Nevus Of Mucosa

External Ear Disease

Diseases Of External Ear	Preauricular Cyst
Preauricular Sinus And Fistula	Preauricular Sinus Or Fistula

Otitis Externa

Swimmer'S Ear	Infective Otitis Externa
Acute Infective Otitis Externa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11231	PRR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRR4	RGD	RGD:735181
Macaca fascicularis	PRR4	NCBI	NCBI:102129177
Mus musculus	PRR4	NCBI
Others	PRR4	NCBI

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