USP18 - ubiquitin specific peptidase 18 Gene

Homo sapiens

Also known as ISG43; UBP43; PTORCH2

Gene ID: 11274 | Gene type: protein coding

About USP18

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:18,150,170-18,177,397 (from NCBI)

This gene has 4 transcripts (splice variants), 121 orthologues, 71 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 6.5), spleen (RPKM 6.3) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of Enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

USP18 Products(1)

mRNA	Protein	Name
NM_017414.4	NP_059110.2	ubl carboxyl-terminal hydrolase 18

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ISG15-specific peptidase activity	EXP EXP: Inferred from Experiment	11788588	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	27801882	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	27801882	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	28165510	GOA
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	27325888	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP18 Protein Structure

UCH

0
100
200
300
372 a.a.

Protein Preferred Names

Protein Names

ubl carboxyl-terminal hydrolase 18

43 kDa ISG15-specific protease

USP18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP18	Q9UMW8	ISG15	Homo sapiens	P05161	Y2H Prey Pooling	25416956
Intra	USP18	Q9UMW8	ISG15	Homo sapiens	P05161	Y2H Prey Pooling	32296183
Intra	USP18	Q9UMW8	ISG15	Homo sapiens	P05161	Anti Bait CoIP	25307056
Intra	USP18	Q9UMW8	ISG15	Homo sapiens	P05161	Y2H Array	32296183
Intra	USP18	Q9UMW8	IFNAR2	Homo sapiens	P48551	Anti Tag CoIP	16710296

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pseudo-Torch Syndrome 2

PTORCH2

Usp18 Deficiency

Torch Syndrome

Immunodeficiency 38 With Basal Ganglia Calcification

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency	IMD38
Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 38
Isg15 Deficiency, Autosomal Recessive	Immunodeficiency 38, With Basal Ganglia Calcification
Autosomal Recessive Isg15 Deficiency	Msmd Due To Complete Isg15 Deficiency
Immunodeficiency, Type 38

Immunodeficiency 44

IMD44

Tuberculous Salpingitis

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Basal Ganglia Calcification

Fahr'S Syndrome	Fahr'S Disease
Fahr Disease

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv
Rvcl	Rvcl-S
Vasculopathy, Retinal, With Cerebral Leukodystrophy	Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Retinal Vasculopathy With Cerebral Leukodystrophy	Retinal Vasculopathy And Cerebral Leukoencephalopathy
Hereditary Vascular Retinopathy	Hvr
RVCLS	Cerebroretinal Vasculopathy, Hereditary
Cerebroretinal Vasculopathy	Herns
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly	Hereditary Cerebroretinal Vasculopathy
Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke	Hereditary Systemic Angiopathy
Hsa	Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations
Adrvcl	Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy
Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke	Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111458	GSK2643943A	Inhibitor	99.12%	Unkown
HY-RS15528	USP18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP18	RGD	RGD:1359153
Mus musculus	USP18	MGD	MGI:1344364

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