2. Gene
  3. KLF12 - KLF transcription factor 12 Gene

KLF12 - KLF transcription factor 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as AP2REP; AP-2rep; HSPC122

Gene ID: 11278 | Gene type: protein coding

About KLF12

Cytogenetic location: 13q22.1 Genomic coordinates (GRCh38): 13:73,686,089-74,306,045 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 22 paralogues. Ubiquitous expression in lymph node (RPKM 6.4), spleen (RPKM 4.4) and 24 other tissues.

Summary

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

KLF12 Products(12)

mRNA Protein Name
NM_001400136.1 NP_001387065.1 Krueppel-like factor 12 isoform 1
NM_001400139.1 NP_001387068.1 Krueppel-like factor 12 isoform 1
NM_001400141.1 NP_001387070.1 Krueppel-like factor 12 isoform 1
NM_001400146.1 NP_001387075.1 Krueppel-like factor 12 isoform 2
NM_001400147.1 NP_001387076.1 Krueppel-like factor 12 isoform 3
NM_001400148.1 NP_001387077.1 Krueppel-like factor 12 isoform 3
NM_001400149.1 NP_001387078.1 Krueppel-like factor 12 isoform 4
NM_001400150.1 NP_001387079.1 Krueppel-like factor 12 isoform 5
NM_001400151.1 NP_001387080.1 Krueppel-like factor 12 isoform 5
NM_001400152.1 NP_001387081.1 Krueppel-like factor 12 isoform 6
NM_001400153.1 NP_001387082.1 Krueppel-like factor 12 isoform 6
NM_007249.5 NP_009180.3 Krueppel-like factor 12 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
16615998 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16615998 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10704285 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10704285 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16615998 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10704285 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF12 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (333 - 350)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (364 - 388)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

Krueppel-like factor 12

AP-2 repressor

KLF12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KLF12 Q9Y4X4 CTBP1 Homo sapiens Q13363-2
Validated Y2H
27107012
Intra
KLF12 Q9Y4X4 CTBP1 Homo sapiens Q13363-2
Y2H Prey Pooling
25416956
Intra
KLF12 Q9Y4X4 CTBP1 Homo sapiens Q13363-2
Y2H Array
25416956
Intra
KLF12 Q9Y4X4 CTBP1 Homo sapiens Q13363-2
BFG-2H
27107012
Intra
KLF12 Q9Y4X4 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
KLF12 Q9Y4X4 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
KLF12 Q9Y4X4 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
KLF12 Q9Y4X4 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
KLF12 Q9Y4X4 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
KLF12 Q9Y4X4 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
25416956
Intra
KLF12 Q9Y4X4 EHMT2 Homo sapiens Q96KQ7
Y2H Prey Pooling
32296183
Intra
KLF12 Q9Y4X4 EHMT2 Homo sapiens Q96KQ7
BioID
35140242
Intra
KLF12 Q9Y4X4 EHMT2 Homo sapiens Q96KQ7
Y2H Array
32296183
Intra
KLF12 Q9Y4X4 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
KLF12 Q9Y4X4 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
KLF12 Q9Y4X4 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07333 KLF12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KLF12 VGNC VGNC:74028
Rattus norvegicus KLF12 RGD RGD:1309204
Felis catus KLF12 VGNC VGNC:102241
Canis familiaris KLF12 VGNC VGNC:42432
Mus musculus KLF12 MGD MGI:1333796
Bos taurus KLF12 VGNC VGNC:30628