VPS26B - VPS26 retromer complex component B Gene

Homo sapiens

Also known as Pep8b

Gene ID: 112936 | Gene type: protein coding

About VPS26B

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,224,671-134,247,788 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 21.5), skin (RPKM 15.9) and 25 other tissues.

Summary

Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in early endosome and late endosome. Predicted to be part of retromer complex. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Apr 2022]

VPS26B Products(1)

mRNA	Protein	Name
NM_052875.5	NP_443107.1	vacuolar protein sorting-associated protein 26B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24980502	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS26B Protein Structure

Vps26

0
100
200
300
336 a.a.

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 26B

vesicle protein sorting 26B

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 56

Mental Retardation, Autosomal Dominant 56	MRD56
Autosomal Dominant Mental Retardation 56	Autosomal Dominant Intellectual Developmental Disorder 56
Autosomal Dominant Intellectual Developmental Disorder-56

Developmental And Epileptic Encephalopathy 48

DEE48	Epileptic Encephalopathy, Early Infantile, 48
Eiee48	Developmental And Epileptic Encephalopathy, 48
Early Infantile Epileptic Encephalopathy 48

Spastic Paraplegia 39, Autosomal Recessive

SPG39	Ntemnd
Hereditary Spastic Paraplegia 39	Nte-Related Motor Neuron Disorder
Autosomal Recessive Spastic Paraplegia Type 39	Spastic Paraplegia Due To Neuropathy Target Esterase Mutation
Spastic Paraplegia Due To Nte Mutation	Spastic Paraplegia 39
Autosomal Recessive Spastic Paraplegia 39	Nte Related Motor Neuron Disorder
Paraplegia, Spastic, Type 39

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15680	VPS26B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VPS26B	MGD	MGI:1917656
Bos taurus	VPS26B	VGNC	VGNC:36815
Canis familiaris	VPS26B	VGNC	VGNC:48281
Rattus norvegicus	VPS26B	RGD	RGD:1597170
Macaca mulatta	VPS26B	VGNC	VGNC:101426
Felis catus	VPS26B	VGNC	VGNC:66961

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