VPS35 - VPS35 retromer complex component Gene

Homo sapiens

Also known as MEM3; PARK17

Gene ID: 55737 | Gene type: protein coding

About VPS35

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,656,132-46,689,178 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 28.7), urinary bladder (RPKM 22.9) and 25 other tissues.

Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

VPS35 Products(1)

mRNA	Protein	Name
NM_018206.6	NP_060676.2	vacuolar protein sorting-associated protein 35

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	27460146	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11102511	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	20164305	GOA
involved in mitochondrial fragmentation involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in mitochondrion to lysosome vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in negative regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	25533483	GOA
involved in negative regulation of late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	23563491	GOA
involved in neurotransmitter receptor transport, endosome to plasma membrane	IDA IDA: Inferred from direct assay	27460146	GOA
involved in positive regulation of dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	27460146	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	26618722	GOA
involved in positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in positive regulation of protein catabolic process	IGI IGI: Inferred from genetic interaction	25533483	GOA
involved in positive regulation of protein localization to cell periphery	IMP IMP: Inferred from mutant phenotype	25533483	GOA
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	28892079	GOA
involved in regulation of dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in regulation of mitochondrion organization	IGI IGI: Inferred from genetic interaction	26618722	GOA
involved in regulation of protein metabolic process	IDA IDA: Inferred from direct assay	26618722	GOA
involved in regulation of protein metabolic process	IGI IGI: Inferred from genetic interaction	25533483	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	18193037	GOA
involved in regulation of terminal button organization	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	15078903	GOA
involved in transcytosis	IDA IDA: Inferred from direct assay	15247922	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	11102511	GOA
located in early endosome	IDA IDA: Inferred from direct assay	18160348	GOA
located in endosome	IDA IDA: Inferred from direct assay	15078903	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	27385586	GOA
colocalizes with mitochondrion	IDA IDA: Inferred from direct assay	26618722	GOA
located in mitochondrion-derived vesicle	IDA IDA: Inferred from direct assay	26618722	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	11102511	GOA
part of retromer, cargo-selective complex	IDA IDA: Inferred from direct assay	20164305	GOA
located in tubular endosome	IDA IDA: Inferred from direct assay	15078903	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS35 Protein Structure

Vps35

0
200
400
600
796 a.a.

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 35

hVPS35

VPS35 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	TSA	24747528
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Anti Tag CoIP	24152121
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Anti Tag CoIP	17891154
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Pull Down	17891154
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Y2H	16732284
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Anti Bait CoIP	11102511
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0-2	Validated Y2H	32296183
Intra	VPS35	Q96QK1	VPS26B	Homo sapiens	Q4G0F5	Anti Tag CoIP	35271311
Intra	VPS35	Q96QK1	VPS26B	Homo sapiens	Q4G0F5	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	TSA	24747528
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Validated Y2H	25416956
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Y2H Prey Pooling	25416956
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	35271311
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	24152121
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	17891154
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	GMS	11102511
Intra	VPS35	Q96QK1	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	33961781
Intra	VPS35	Q96QK1	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	35271311
Intra	VPS35	Q96QK1	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	37172566
Cross	VPS35	Q96QK1	Vps29	Mus musculus	Q9QZ88	ITC	24152121
Intra	VPS35	Q96QK1	WASHC2C	Homo sapiens	Q9Y4E1	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	WASHC2C	Homo sapiens	Q9Y4E1	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Parkinson Disease 17

PARK17	Parkinson'S Disease 17
Autosomal Dominant Parkinson Disease 17	Parkinson Disease, Type 17

Hereditary Late-Onset Parkinson Disease

Autosomal Dominant Late-Onset Parkinson Disease	Lopd
Hereditary Late Onset Parkinson Disease

Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3

Glioma

Parkinson Disease 21

PARK21	Parkinson'S Disease 21
Parkinson Disease, Type 21

Kufor-Rakeb Syndrome

Park9	Krppd
KRS	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia
Autosomal Recessive Parkinson Disease 9	Parkinson Disease 9
Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset	Autosomal Recessive Juvenile Onset Parkinson Disease 9
Parkinson Disease Type 9	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia
Park 9	Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis
Cln12 Disease	Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis
Parkinson Disease Autosomal Recessive 9

Early-Onset Parkinson'S Disease

Early-Onset Parkinson Disease

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome	Pallidopyramidal Syndrome
Parkinson Disease 15, Autosomal Recessive	PARK15
Pkps	Pallido-Pyramidal Syndrome
Parkinson'S Disease 15	Autosomal Recessive Early-Onset Parkinson Disease 15
Autosomal Recessive Early-Onset Parkinson'S Disease 15	Pallido-Pyramidal Disease
Parkinson Disease 15	Parkinson Disease 15 Autosomal Recessive
Pps	Parkinson Disease, Type 15

Neuroaxonal Dystrophy

Neuroaxonal Dystrophies

Movement Disease

Movement Disorders

Movement Disorder

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Gaucher'S Disease

Gaucher Disease	Kerasin Thesaurismosis
Glucocerebrosidase Deficiency	Glucosylceramidase Deficiency
Cerebroside Lipidosis Syndrome	Acid Beta-Glucosidase Deficiency
Glucosylceramide Beta-Glucosidase Deficiency	Acute Cerebral Gaucher Disease
Gaucher Splenomegaly	Glucocerebrosidosis
Glucosyl Cerebroside Lipidosis	Kerasin Lipoidosis
Lipoid Histiocytosis	Glocucerebrosidase Deficiency
Sphingolipidosis 1	Gaucher Syndrome
Gauchers Disease	Gd
Glucosylceramide Lipidosis	Kerasin Histiocytosis
Gaucher Disease, Type 1	Gaucher Disease, Type 2

Gaucher Disease, Type I

Glucocerebrosidase Deficiency	Acid Beta-Glucosidase Deficiency
Gba Deficiency	GD1
Gd I	Gaucher Disease, Noncerebral Juvenile
Gaucher Disease Type 1	Gaucher Disease Type I
Gaucher'S Disease Type I	Gaucher Disease
Gd 1	Non-Cerebral Juvenile Gaucher Disease
GD	Gaucher Disease 1
Adult Non-Neuronopathic Gaucher Disease	Noncerebral Juvenile Gaucher Disease
Type 1 Gaucher Disease	Gaucher Disease, Type 1

Sphingolipidosis

Sphingolipidoses

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy	Steele-Richardson-Olszewski Syndrome
Supranuclear Palsy, Progressive	Progressive Supranuclear Ophthalmoplegia
Psp	PSNP1
Familial Progressive Supranuclear Palsy	Richardson'S Syndrome
Psp Syndrome	Progressive Supranuclear Palsy 1
Supranuclear Palsy Progressive	Ophthalmoplegia, Supranuclear, Progressive
Steele-Richardson-Olszewksi Syndrome

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15685	VPS35 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15686	VPS35L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VPS35	VGNC	VGNC:36818
Felis catus	VPS35	VGNC	VGNC:66964
Canis familiaris	VPS35	VGNC	VGNC:48285
Rattus norvegicus	VPS35	RGD	RGD:1589784
Macaca mulatta	VPS35	VGNC	VGNC:78928
Mus musculus	VPS35	MGD	MGI:1890467

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