CDCA5 - cell division cycle associated 5 Gene

Homo sapiens

Also known as SORORIN

Gene ID: 113130 | Gene type: protein coding

About CDCA5

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,061,093-65,084,040 (from NCBI)

This gene has 10 transcripts (splice variants) and 170 orthologues. Biased expression in bone marrow (RPKM 12.1), testis (RPKM 11.0) and 13 other tissues.

Summary

Predicted to enable chromatin binding activity. Involved in double-strand break repair; mitotic sister chromatid segregation; and regulation of cell cycle process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CDCA5 Products(1)

mRNA	Protein	Name
NM_080668.4	NP_542399.1	sororin

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21111234	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15837422	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	17349791	GOA
involved in mitotic cell cycle	IDA IDA: Inferred from direct assay	15837422	GOA
involved in mitotic chromosome condensation	IMP IMP: Inferred from mutant phenotype	15837422	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	15837422	GOA
involved in mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	17349791	GOA
involved in mitotic sister chromatid cohesion	IPI IPI: Inferred from physical interaction	21111234	GOA
involved in positive regulation of exit from mitosis	IMP IMP: Inferred from mutant phenotype	23548868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA5 Protein Structure

Sororin

0
100
200
252 a.a.

Protein Preferred Names

Protein Names

sororin

cell division cycle-associated protein 5

CDCA5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDCA5	Q96FF9	PDS5A	Homo sapiens	Q29RF7	Anti Bait CoIP	21111234
Intra	CDCA5	Q96FF9	PDS5A	Homo sapiens	Q29RF7	Anti Tag CoIP	26496610
Intra	CDCA5	Q96FF9	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	CDCA5	Q96FF9	NAA10	Homo sapiens	P41227	Anti Tag CoIP	33961781
Intra	CDCA5	Q96FF9	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	33961781
Intra	CDCA5	Q96FF9	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Roberts-Sc Phocomelia Syndrome

Roberts Syndrome	Sc Phocomelia Syndrome
RBS	Long Bone Deficiencies Associated With Cleft Lip-Palate
Sc Pseudothalidomide Syndrome	Appelt-Gerken-Lenz Syndrome
Pseudothalidomide Syndrome	Tetraphocomelia-Cleft Palate Syndrome
Hypomelia Hypotrichosis Facial Hemangioma Syndrome	Roberts Syndrome/Sc Phocomelia
Roberts Tetraphocomelia Syndrome	Sc Syndrome
Sc Phocomelia	Sc Disease
Sc	Hemoglobin Sc Disease

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02314	CDCA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDCA5	VGNC	VGNC:39015
Felis catus	CDCA5	VGNC	VGNC:60667
Bos taurus	CDCA5	VGNC	VGNC:56261
Mus musculus	CDCA5	MGD	MGI:1915099
Rattus norvegicus	CDCA5	RGD	RGD:1560863
Macaca mulatta	CDCA5	VGNC	VGNC:100907

Name
Email *

	Sorry, but the email address you supplied was invalid.