PDS5A - PDS5 cohesin associated factor A Gene

Homo sapiens

Also known as PIG54; SCC112; SCC-112

Gene ID: 23244 | Gene type: protein coding

About PDS5A

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,822,863-39,977,911 (from NCBI)

This gene has 10 transcripts (splice variants), 226 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 18.1), lymph node (RPKM 17.1) and 25 other tissues.

Summary

The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

PDS5A Products(2)

mRNA	Protein	Name
NM_001100399.2	NP_001093869.1	sister chromatid cohesion protein PDS5 homolog A isoform 1
NM_001100400.2	NP_001093870.1	sister chromatid cohesion protein PDS5 homolog A isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15837422	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic sister chromatid cohesion	IPI IPI: Inferred from physical interaction	21111234	GOA
involved in negative regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	19907496	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	16682347	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sister chromatid cohesion protein PDS5 homolog A

PDS5, regulator of cohesion maintenance, homolog A

PDS5A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDS5A	Q29RF7	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	17113138
Intra	PDS5A	Q29RF7	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	15855230
Intra	PDS5A	Q29RF7	STAG1	Homo sapiens	Q8WVM7	Anti Bait CoIP	17113138
Intra	PDS5A	Q29RF7	STAG1	Homo sapiens	Q8WVM7	Anti Bait CoIP	15855230
Intra	PDS5A	Q29RF7	CDCA5	Homo sapiens	Q96FF9	Anti Bait CoIP	21111234
Intra	PDS5A	Q29RF7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	17113138
Intra	PDS5A	Q29RF7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	15855230
Intra	PDS5A	Q29RF7	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17113138
Intra	PDS5A	Q29RF7	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17112726
Intra	PDS5A	Q29RF7	RAD21	Homo sapiens	O60216	Anti Bait CoIP	15855230

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Roberts-Sc Phocomelia Syndrome

Roberts Syndrome	Sc Phocomelia Syndrome
RBS	Long Bone Deficiencies Associated With Cleft Lip-Palate
Sc Pseudothalidomide Syndrome	Appelt-Gerken-Lenz Syndrome
Pseudothalidomide Syndrome	Tetraphocomelia-Cleft Palate Syndrome
Hypomelia Hypotrichosis Facial Hemangioma Syndrome	Roberts Syndrome/Sc Phocomelia
Roberts Tetraphocomelia Syndrome	Sc Syndrome
Sc Phocomelia	Sc Disease
Sc	Hemoglobin Sc Disease

Somatization Disorder

Somatoform Disorders	Briquet'S Disorder
Polysomatising Disorder	Somatisation Disorder
Somatoform Disorder

Warsaw Breakage Syndrome

WABS

WBRS

Chronic Atrial And Intestinal Dysrhythmia

CAID	Caid Syndrome
Cohesinopathy Affecting Heart And Gut Rhythm	Chronic Atrial Intestinal Dysrhythmia Syndrome
Chronic Atrial And Intestinal Dysrhythmia Syndrome	Chronic Atrial Dysrhythmia-Intestinal Motility Disorder
Dysrhythmia, Atrial And Intestinal, Chronic

Familial Isolated Trichomegaly

Long Eyelashes

Tcmgly

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10291	PDS5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PDS5A	RGD	RGD:1307094
Bos taurus	PDS5A	VGNC	VGNC:32717
Felis catus	PDS5A	VGNC	VGNC:64097
Macaca mulatta	PDS5A	VGNC	VGNC:100261
Canis familiaris	PDS5A	VGNC	VGNC:44392
Mus musculus	PDS5A	MGD	MGI:1918771

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