2. Gene
  3. DDX42 - DEAD-box helicase 42 Gene

DDX42 - DEAD-box helicase 42 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RHELP; RNAHP; SF3B8; DDX42P; SF3b125

Gene ID: 11325 | Gene type: protein coding

About DDX42

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,773,800-63,819,317 (from NCBI)

This gene has 18 transcripts (splice variants), 211 orthologues and 38 paralogues. Ubiquitous expression in testis (RPKM 27.4), ovary (RPKM 25.5) and 25 other tissues.

Summary

This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

DDX42 Products(2)

mRNA Protein Name
NM_007372.3 NP_031398.2 ATP-dependent RNA helicase DDX42
NM_203499.3 NP_987095.1 ATP-dependent RNA helicase DDX42

DDX42 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (277 - 448)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (517 - 593)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 938 a.a.
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DDX42

DEAD (Asp-Glu-Ala-Asp) box helicase 42

DDX42 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DDX42 Q86XP3 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03650 DDX42 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DDX42 VGNC VGNC:39858
Felis catus DDX42 VGNC VGNC:61409
Bos taurus DDX42 VGNC VGNC:27968
Macaca mulatta DDX42 VGNC VGNC:71661
Mus musculus DDX42 MGD MGI:1919297
Rattus norvegicus DDX42 RGD RGD:1304909