SF3A2 - splicing factor 3a subunit 2 Gene

Homo sapiens

Also known as PRP11; SAP62; PRPF11; SF3a66

Gene ID: 8175 | Gene type: protein coding

About SF3A2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,236,824-2,248,655 (from NCBI)

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 28.5), ovary (RPKM 22.4) and 25 other tissues.

Summary

This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

SF3A2 Products(1)

mRNA	Protein	Name
NM_007165.5	NP_009096.2	splicing factor 3A subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17332742	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in U2-type prespliceosome assembly	IDA IDA: Inferred from direct assay	11533230	GOA
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	15647371	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	29360106	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2 snRNP	IDA IDA: Inferred from direct assay	11533230	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	29360106	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U2-type spliceosomal complex	IPI IPI: Inferred from physical interaction	10882114	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18559850	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	9731529	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3A2 Protein Structure

zf-met

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

splicing factor 3A subunit 2

SAP 62

SF3A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SF3A2	Q15428	SNRNP200	Homo sapiens	O75643	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SNRNP200	Homo sapiens	O75643	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	DNAJC8	Homo sapiens	O75937	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SF3B6	Homo sapiens	Q9Y3B4	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	PLRG1	Homo sapiens	O43660	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SF3A3	Homo sapiens	Q12874	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SNRPB2	Homo sapiens	P08579	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SF3A1	Homo sapiens	Q15459	Crosslink	30021884
Intra	SF3A2	Q15428	SF3A1	Homo sapiens	Q15459	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SF3A1	Homo sapiens	Q15459	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SF3A1	Homo sapiens	Q15459	Y2H	22365833
Intra	SF3A2	Q15428	DHX15	Homo sapiens	O43143	Affinity Chrom	17332742
Intra	SF3A2	Q15428	LIN54	Homo sapiens	Q6MZP7	Validated Y2H	32296183
Intra	SF3A2	Q15428	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
Intra	SF3A2	Q15428	PHF5A	Homo sapiens	Q7RTV0	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SF3B5	Homo sapiens	Q9BWJ5	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SNRPD2	Homo sapiens	P62316	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SNRPD2	Homo sapiens	P62316	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SF3B3	Homo sapiens	Q15393	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SNRPE	Homo sapiens	P62304	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SF3B4	Homo sapiens	Q15427	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SF3B4	Homo sapiens	Q15427	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	HSPA8	Homo sapiens	P11142	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SNRPF	Homo sapiens	P62306	Affinity Chrom	17332742
Intra	SF3A2	Q15428	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	SF3A2	Q15428	EFTUD2	Homo sapiens	Q15029	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SNRPD1	Homo sapiens	P62314	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SNRPD1	Homo sapiens	P62314	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SNRPB	Homo sapiens	P14678	Affinity Chrom	17332742
Intra	SF3A2	Q15428	CDC5L	Homo sapiens	Q99459	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	CDC5L	Homo sapiens	Q99459	Affinity Chrom	17332742
Intra	SF3A2	Q15428	ACIN1	Homo sapiens	Q9UKV3	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	NCBP1	Homo sapiens	Q09161	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	PRPF6	Homo sapiens	O94906	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	PRPF6	Homo sapiens	O94906	Affinity Chrom	17332742
Intra	SF3A2	Q15428	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	DDX23	Homo sapiens	Q9BUQ8	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SART1	Homo sapiens	O43290	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SART1	Homo sapiens	O43290	Affinity Chrom	17332742
Intra	SF3A2	Q15428	TRIP10	Homo sapiens	Q15642-2	Validated Y2H	32296183
Intra	SF3A2	Q15428	PNN	Homo sapiens	Q9H307	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	PNN	Homo sapiens	Q9H307	Affinity Chrom	17332742
Intra	SF3A2	Q15428	HTATSF1	Homo sapiens	O43719	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	HTATSF1	Homo sapiens	O43719	Affinity Chrom	17332742
Intra	SF3A2	Q15428	DDX42	Homo sapiens	Q86XP3	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	TRA2B	Homo sapiens	P62995	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	PRPF3	Homo sapiens	O43395	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SF1	Homo sapiens	Q15637	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SF3B2	Homo sapiens	Q13435	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SF3B2	Homo sapiens	Q13435	Affinity Chrom	17332742
Intra	SF3A2	Q15428	SNRPA1	Homo sapiens	P09661	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SF3B1	Homo sapiens	O75533	Anti Tag CoIP	35271311
Intra	SF3A2	Q15428	SF3B1	Homo sapiens	O75533	Affinity Chrom	17332742
Intra	SF3A2	Q15428	BAIAP2	Homo sapiens	Q9UQB8-6	Validated Y2H	32296183
Intra	SF3A2	Q15428	BEND2	Homo sapiens	Q8NDZ0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12758	SF3A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12761	SF3B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SF3A2	MGD	MGI:104912
Rattus norvegicus	SF3A2	RGD	RGD:1308627
Felis catus	SF3A2	VGNC	VGNC:65053
Bos taurus	SF3A2	VGNC	VGNC:34507
Macaca mulatta	SF3A2	VGNC	VGNC:77178
Canis familiaris	SF3A2	VGNC	VGNC:46068

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