TMEM106A - transmembrane protein 106A Gene

Homo sapiens

Gene ID: 113277 | Gene type: protein coding

About TMEM106A

This gene has 8 transcripts (splice variants) and 111 orthologues. Broad expression in kidney (RPKM 9.2), appendix (RPKM 4.7) and 23 other tissues.

Summary

Predicted to be involved in several processes, including glycoprotein biosynthetic process; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM106A Products(4)

mRNA	Protein	Name
NM_001291586.2	NP_001278515.1	transmembrane protein 106A isoform a
NM_001291587.2	NP_001278516.1	transmembrane protein 106A isoform b
NM_001291588.2	NP_001278517.1	transmembrane protein 106A isoform c
NM_145041.4	NP_659478.1	transmembrane protein 106A isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM106A Protein Structure

DUF1356

0
100
200
262 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 106A

TMEM106A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMEM106A	Q96A25	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	TMEM106A	Q96A25	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	TMEM106A	Q96A25	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	TMEM106A	Q96A25	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	TMEM106A	Q96A25	TMEM106C	Homo sapiens	Q9BVX2	Anti Tag CoIP	33961781
Intra	TMEM106A	Q96A25	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14645	TMEM106A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMEM106A	VGNC	VGNC:47446
Rattus norvegicus	TMEM106A	RGD	RGD:1309043
Bos taurus	TMEM106A	VGNC	VGNC:35944
Mus musculus	TMEM106A	MGD	MGI:1922056
Macaca mulatta	TMEM106A	VGNC	VGNC:79695
Felis catus	TMEM106A	VGNC	VGNC:66256

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