MGLL - monoglyceride lipase Gene

Homo sapiens

Also known as MGL; HUK5; MAGL; HU-K5

Gene ID: 11343 | Gene type: protein coding

About MGLL

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,689,066-127,823,185 (from NCBI)

This gene has 13 transcripts (splice variants) and 209 orthologues. Broad expression in fat (RPKM 103.8), esophagus (RPKM 51.9) and 19 other tissues.

Summary

This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in Cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

MGLL Products(10)

mRNA	Protein	Name
NM_001003794.3	NP_001003794.1	monoglyceride lipase isoform 2
NM_001256585.2	NP_001243514.1	monoglyceride lipase isoform 3
NM_001388312.1	NP_001375241.1	monoglyceride lipase isoform 4
NM_001388313.1	NP_001375242.1	monoglyceride lipase isoform 5
NM_001388314.1	NP_001375243.1	monoglyceride lipase isoform 6
NM_001388315.1	NP_001375244.1	monoglyceride lipase isoform 7
NM_001388316.1	NP_001375245.1	monoglyceride lipase isoform 8
NM_001388317.1	NP_001375246.1	monoglyceride lipase isoform 9
NM_001388318.1	NP_001375247.1	monoglyceride lipase isoform 9
NM_007283.7	NP_009214.1	monoglyceride lipase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoacylglycerol lipase activity	IDA IDA: Inferred from direct assay	22969151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28298427	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19957260	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acylglycerol catabolic process	IDA IDA: Inferred from direct assay	22969151	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGLL Protein Structure

Abhydrolase_6

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

monoglyceride lipase

lysophospholipase homolog

MGLL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MGLL	Q99685	ADRB2	Homo sapiens	P07550	Anti Bait CoIP	28298427
Intra	MGLL	Q99685	ADRB2	Homo sapiens	P07550	Ub Reconstruction	28298427
Intra	MGLL	Q99685	HPCAL1	Homo sapiens	P37235	Anti Tag CoIP	28514442
Intra	MGLL	Q99685	HPCAL1	Homo sapiens	P37235	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

MGLL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83201	Monoacylglycerol Lipase Antibody (YA2946)	WB	Human

Related Diseases

Diseases

Alias

Hallucinogen Dependence

Hallucinogen Addiction

Cannabis Dependence

Marijuana Abuse	Cannabinoid Addiction
Cannabinoid Dependence	Cannabis Addiction

Cannabis Abuse

Marijuana Abuse

Chanarin-Dorfman Syndrome

Neutral Lipid Storage Disease	CDS
Neutral Lipid Storage Disease With Ichthyosis	Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation
Triglyceride Storage Disease With Ichthyosis	Nlsdi
Ichthyotic Neutral Lipid Storage Disease	Dorfman-Chanarin Syndrome
Dcs	Chanarin-Dorfman Disease
Ichthyosiform Erythroderma With Leukocyte Vacuolation	Lipidosis With Triglyceride Storage Disease
Disorder Of Cornification 12	Dorfman Chanarin Syndrome
Neutral Lipid Storage Disease With Ichthyotic	Dorfman-Chanarin Disease

Uvulitis

Acute Uvulitis

Pain Agnosia

Analgesia

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Lennox-Gastaut Syndrome

Lennox Syndrome	Encephalopathy Of Childhood
Epileptic Encephalopathy Lennox-Gastaut Type	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18540	KT109	Inhibitor	99.82%	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124576	ABD-1970	Inhibitor	/	Unkown
HY-RS08409	MGLL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MGLL	MGD	MGI:1346042
Canis familiaris	MGLL	VGNC	VGNC:54327
Felis catus	MGLL	VGNC	VGNC:63489
Macaca mulatta	MGLL	VGNC	VGNC:74523
Bos taurus	MGLL	VGNC	VGNC:54454
Rattus norvegicus	MGLL	RGD	RGD:71039
Others	MGLL	NCBI

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