SDSL - serine dehydratase like Gene

Homo sapiens

Also known as TDH; cSDH; SDH 2; SDS-RS1

Gene ID: 113675 | Gene type: protein coding

About SDSL

This gene has 6 transcripts (splice variants), 199 orthologues and 5 paralogues. Broad expression in kidney (RPKM 8.5), thyroid (RPKM 7.2) and 24 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in isoleucine biosynthetic process and threonine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SDSL Products(2)

mRNA	Protein	Name
NM_001304993.2	NP_001291922.1	serine dehydratase-like
NM_138432.4	NP_612441.1	serine dehydratase-like

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-serine ammonia-lyase activity	IDA IDA: Inferred from direct assay	16580895	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables threonine deaminase activity	IDA IDA: Inferred from direct assay	16580895	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDSL Protein Structure

PALP

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

serine dehydratase-like

L-serine deaminase

SDSL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SDSL	Q96GA7	SDSL	Homo sapiens	Q96GA7	Validated Y2H	32296183
Intra	SDSL	Q96GA7	SDSL	Homo sapiens	Q96GA7	Y2H Array	25416956
Intra	SDSL	Q96GA7	SDSL	Homo sapiens	Q96GA7	Y2H Prey Pooling	32296183
Intra	SDSL	Q96GA7	SDSL	Homo sapiens	Q96GA7	Y2H Array	32296183
Intra	SDSL	Q96GA7	SDSL	Homo sapiens	Q96GA7	Y2H Array	31515488
Intra	SDSL	Q96GA7	SDSL	Homo sapiens	Q96GA7	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sarcocystosis

Sarcosporidiosis

Sarcosporidiasis

Subdural Empyema

Empyema, Subdural

Subdural Abscess

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12600	SDSL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-130509	MTSSL		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SDSL	VGNC	VGNC:34400
Canis familiaris	SDSL	VGNC	VGNC:45959
Felis catus	SDSL	VGNC	VGNC:64958
Mus musculus	SDSL	MGD	MGI:2182607
Macaca mulatta	SDSL	VGNC	VGNC:77347
Rattus norvegicus	SDSL	RGD	RGD:1309192

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