P2rx2 - purinergic receptor P2X 2 Gene

Rattus norvegicus

Also known as P2X2

Gene ID: 114115 | Gene type: protein coding

About P2rx2

Primary_assembly 12: 46,339,549-46,342,891 forward strand.mRatBN7.2:CM026985.1

This gene has 3 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in Testes (RPKM 23.9), Uterus (RPKM 1.3) and 7 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including neuronal action potential; regulation of presynaptic cytosolic calcium ion concentration; and response to ischemia. Located in several cellular components, including dendritic spine; postsynaptic density; and presynaptic membrane. Is integral component of membrane. Part of receptor complex. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]

P2rx2 Products(2)

mRNA	Protein	Name
NM_053656.3	NP_446108.2	P2X purinoceptor 2
NM_053656.3	NP_446108.2	P2X purinoceptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16190872	RGD
enables cadmium ion binding	IDA IDA: Inferred from direct assay	16190872	RGD
enables cobalt ion binding	IDA IDA: Inferred from direct assay	16190872	RGD
enables copper ion binding	IDA IDA: Inferred from direct assay	16190872	RGD
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	16190872	RGD
enables extracellularly ATP-gated monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	15317863	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15313628	RGD
enables ligand-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	7542879	RGD
enables mercury ion binding	IDA IDA: Inferred from direct assay	16190872	RGD
enables nickel cation binding	IDA IDA: Inferred from direct assay	16190872	RGD
enables phosphatidylinositol binding	IMP IMP: Inferred from mutant phenotype	16857707	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16330549	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15313628	RGD
enables purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	16388598	RGD
enables suramin binding	IDA IDA: Inferred from direct assay	16388598	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	16190872	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuronal action potential	IDA IDA: Inferred from direct assay	16190872	RGD
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	15317863	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	EXP EXP: Inferred from Experiment	16000618	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	16000618	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IEP IEP: Inferred from expression pattern	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	IEP IEP: Inferred from expression pattern	16000618	RGD
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	12849743	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	16388598	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	16330549	RGD
located in cell surface	IDA IDA: Inferred from direct assay	18616429	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11160443	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	16000618	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11160443	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10974431	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	11160443	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15313628	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	11160443	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	16000618	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	10974431	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	15313628	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	10974431	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx2 Protein Structure

P2X

0
100
200
300
400
497 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 2

ATP receptor

purinergic receptor P2X, ligand-gated ion channel, 2

P2rx2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	P2rx2	P49653	P2rx6	Rattus norvegicus	P51579	IF	24815693
Intra	P2rx2	P49653	P2rx4	Rattus norvegicus	P51577	IF	24815693

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09900	P2RX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09901	P2rx2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09902	P2rx2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2rx2	NCBI	NCBI:22953

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